Adverse Drug Reaction Monitoring of Anticancer Drugs in Hematology Department

Background: Cancer is among the leading causes of mortality in India. Studies have reported antineoplastic agents as the common class of drugs causing Adverse Drug Reactions (ADRs). The present study aimed to conduct active surveillance of ADRs of anticancer drugs in the hematology department. Meth...

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Autores principales:	Ghazal Roohi, Panner Selvam R, Fares Najari
Formato:	article
Lenguaje:	EN
Publicado:	Shaheed Beheshti University of Medical Sciences 2021
Materias:	adverse drug reaction anticancer agents active surveillance leukemic leukemia Medicine (General) R5-920 Toxicology. Poisons RA1190-1270
Acceso en línea:	https://doi.org/10.32598/ijmtfm.v11i3.32776 https://doaj.org/article/e343264067c141a68c170d4acf3b70cc
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spelling	oai:doaj.org-article:e343264067c141a68c170d4acf3b70cc2021-11-08T07:49:35ZAdverse Drug Reaction Monitoring of Anticancer Drugs in Hematology Departmenthttps://doi.org/10.32598/ijmtfm.v11i3.327762251-87622251-8770https://doaj.org/article/e343264067c141a68c170d4acf3b70cc2021-08-01T00:00:00Zhttps://journals.sbmu.ac.ir/ijmtfm/article/view/32776https://doaj.org/toc/2251-8762https://doaj.org/toc/2251-8770Background: Cancer is among the leading causes of mortality in India. Studies have reported antineoplastic agents as the common class of drugs causing Adverse Drug Reactions (ADRs). The present study aimed to conduct active surveillance of ADRs of anticancer drugs in the hematology department. Methods: A prospective observational study was conducted in 136 patients with cancer and the incidence and frequency of ADRs were assessed. The study was conducted in 6 months in a multispecialty hospital. Results: Among 136 cancer patients, All was more prevalent (39.70%); CLL, Non- Hodgkin’s Lymphoma were less prevalent (0.73%). ADRs were more prevalent in the Pediatrics department, i.e., 18.53% of ADRs were observed in patients aged <10 years. ADRs in male patients constituted 54.39%, whereas it was 45.60% in female patients. Cytarabine caused the highest number of ADRs (34.48%). The most prevalent ADR was anemia (25.60%). Conclusion: Multiple ADRs were detected in cancer patients. We found that hematological ADRs were more prevalent. Most of the ADRs were possible reactions according to Naranjo and the World Health Organization (WHO) scales.Ghazal RoohiPanner Selvam RFares NajariShaheed Beheshti University of Medical Sciencesarticleadverse drug reactionanticancer agentsactive surveillanceleukemic leukemiaMedicine (General)R5-920Toxicology. PoisonsRA1190-1270ENInternational Journal of Medical Toxicology and Forensic Medicine, Vol 11, Iss 3, p 32776 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adverse drug reaction anticancer agents active surveillance leukemic leukemia Medicine (General) R5-920 Toxicology. Poisons RA1190-1270
spellingShingle	adverse drug reaction anticancer agents active surveillance leukemic leukemia Medicine (General) R5-920 Toxicology. Poisons RA1190-1270 Ghazal Roohi Panner Selvam R Fares Najari Adverse Drug Reaction Monitoring of Anticancer Drugs in Hematology Department
description	Background: Cancer is among the leading causes of mortality in India. Studies have reported antineoplastic agents as the common class of drugs causing Adverse Drug Reactions (ADRs). The present study aimed to conduct active surveillance of ADRs of anticancer drugs in the hematology department. Methods: A prospective observational study was conducted in 136 patients with cancer and the incidence and frequency of ADRs were assessed. The study was conducted in 6 months in a multispecialty hospital. Results: Among 136 cancer patients, All was more prevalent (39.70%); CLL, Non- Hodgkin’s Lymphoma were less prevalent (0.73%). ADRs were more prevalent in the Pediatrics department, i.e., 18.53% of ADRs were observed in patients aged <10 years. ADRs in male patients constituted 54.39%, whereas it was 45.60% in female patients. Cytarabine caused the highest number of ADRs (34.48%). The most prevalent ADR was anemia (25.60%). Conclusion: Multiple ADRs were detected in cancer patients. We found that hematological ADRs were more prevalent. Most of the ADRs were possible reactions according to Naranjo and the World Health Organization (WHO) scales.
format	article
author	Ghazal Roohi Panner Selvam R Fares Najari
author_facet	Ghazal Roohi Panner Selvam R Fares Najari
author_sort	Ghazal Roohi
title	Adverse Drug Reaction Monitoring of Anticancer Drugs in Hematology Department
title_short	Adverse Drug Reaction Monitoring of Anticancer Drugs in Hematology Department
title_full	Adverse Drug Reaction Monitoring of Anticancer Drugs in Hematology Department
title_fullStr	Adverse Drug Reaction Monitoring of Anticancer Drugs in Hematology Department
title_full_unstemmed	Adverse Drug Reaction Monitoring of Anticancer Drugs in Hematology Department
title_sort	adverse drug reaction monitoring of anticancer drugs in hematology department
publisher	Shaheed Beheshti University of Medical Sciences
publishDate	2021
url	https://doi.org/10.32598/ijmtfm.v11i3.32776 https://doaj.org/article/e343264067c141a68c170d4acf3b70cc
work_keys_str_mv	AT ghazalroohi adversedrugreactionmonitoringofanticancerdrugsinhematologydepartment AT pannerselvamr adversedrugreactionmonitoringofanticancerdrugsinhematologydepartment AT faresnajari adversedrugreactionmonitoringofanticancerdrugsinhematologydepartment
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Adverse Drug Reaction Monitoring of Anticancer Drugs in Hematology Department

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