Consumption of Non-Nutritive Sweetener, Acesulfame Potassium Exacerbates Atherosclerosis through Dysregulation of Lipid Metabolism in ApoE<sup>−/−</sup> Mice

Obesity is associated with the risk of cardiovascular disease, and non-nutritive sweetener, such as acesulfame potassium (AceK) has been used to combat obesity. However, the effects of AceK on cardiovascular disease are still unclear. In this study, high cholesterol diet (HCD)-fed ApoE<sup>−/−...

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Autores principales:	Cheng-Hsin Lin, Hung-Yuan Li, Shu-Huei Wang, Yue-Hwa Chen, Yang-Ching Chen, Hung-Tsung Wu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	acesulfame potassium apolipoprotein E atherosclerosis dysregulation lipid metabolism Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/e344a676d2c1416bb06f8054549ff4fb
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spelling	oai:doaj.org-article:e344a676d2c1416bb06f8054549ff4fb2021-11-25T18:35:48ZConsumption of Non-Nutritive Sweetener, Acesulfame Potassium Exacerbates Atherosclerosis through Dysregulation of Lipid Metabolism in ApoE<sup>−/−</sup> Mice10.3390/nu131139842072-6643https://doaj.org/article/e344a676d2c1416bb06f8054549ff4fb2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3984https://doaj.org/toc/2072-6643Obesity is associated with the risk of cardiovascular disease, and non-nutritive sweetener, such as acesulfame potassium (AceK) has been used to combat obesity. However, the effects of AceK on cardiovascular disease are still unclear. In this study, high cholesterol diet (HCD)-fed ApoE<sup>−/−</sup> mice had dysregulated plasma lipid profile, and developed atherosclerosis, determined by atherosclerotic plaque in the aorta. Supplement of AceK in HCD worsened the dyslipidemia and increased atherosclerotic plaque, as compared with HCD-fed ApoE<sup>−/−</sup> mice. Since treatment of AceK in RAW264.7 macrophages showed no significant effects on inflammatory cytokine expressions, we then investigated the impacts of AceK on lipid metabolism. We found that AceK consumption enhanced hepatic lipogenesis and decreased β-oxidation in ApoE<sup>−/−</sup> mice. In addition, AceK directly increased lipogenesis and decreased β-oxidation in HepG2 cells. Taken together, a concurrent consumption of AceK exacerbated HCD-induced dyslipidemia and atherosclerotic lesion in ApoE<sup>−/−</sup> mice, and AceK might increase the risk of atherosclerosis under HCD.Cheng-Hsin LinHung-Yuan LiShu-Huei WangYue-Hwa ChenYang-Ching ChenHung-Tsung WuMDPI AGarticleacesulfame potassiumapolipoprotein Eatherosclerosisdysregulationlipid metabolismNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3984, p 3984 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acesulfame potassium apolipoprotein E atherosclerosis dysregulation lipid metabolism Nutrition. Foods and food supply TX341-641
spellingShingle	acesulfame potassium apolipoprotein E atherosclerosis dysregulation lipid metabolism Nutrition. Foods and food supply TX341-641 Cheng-Hsin Lin Hung-Yuan Li Shu-Huei Wang Yue-Hwa Chen Yang-Ching Chen Hung-Tsung Wu Consumption of Non-Nutritive Sweetener, Acesulfame Potassium Exacerbates Atherosclerosis through Dysregulation of Lipid Metabolism in ApoE<sup>−/−</sup> Mice
description	Obesity is associated with the risk of cardiovascular disease, and non-nutritive sweetener, such as acesulfame potassium (AceK) has been used to combat obesity. However, the effects of AceK on cardiovascular disease are still unclear. In this study, high cholesterol diet (HCD)-fed ApoE<sup>−/−</sup> mice had dysregulated plasma lipid profile, and developed atherosclerosis, determined by atherosclerotic plaque in the aorta. Supplement of AceK in HCD worsened the dyslipidemia and increased atherosclerotic plaque, as compared with HCD-fed ApoE<sup>−/−</sup> mice. Since treatment of AceK in RAW264.7 macrophages showed no significant effects on inflammatory cytokine expressions, we then investigated the impacts of AceK on lipid metabolism. We found that AceK consumption enhanced hepatic lipogenesis and decreased β-oxidation in ApoE<sup>−/−</sup> mice. In addition, AceK directly increased lipogenesis and decreased β-oxidation in HepG2 cells. Taken together, a concurrent consumption of AceK exacerbated HCD-induced dyslipidemia and atherosclerotic lesion in ApoE<sup>−/−</sup> mice, and AceK might increase the risk of atherosclerosis under HCD.
format	article
author	Cheng-Hsin Lin Hung-Yuan Li Shu-Huei Wang Yue-Hwa Chen Yang-Ching Chen Hung-Tsung Wu
author_facet	Cheng-Hsin Lin Hung-Yuan Li Shu-Huei Wang Yue-Hwa Chen Yang-Ching Chen Hung-Tsung Wu
author_sort	Cheng-Hsin Lin
title	Consumption of Non-Nutritive Sweetener, Acesulfame Potassium Exacerbates Atherosclerosis through Dysregulation of Lipid Metabolism in ApoE<sup>−/−</sup> Mice
title_short	Consumption of Non-Nutritive Sweetener, Acesulfame Potassium Exacerbates Atherosclerosis through Dysregulation of Lipid Metabolism in ApoE<sup>−/−</sup> Mice
title_full	Consumption of Non-Nutritive Sweetener, Acesulfame Potassium Exacerbates Atherosclerosis through Dysregulation of Lipid Metabolism in ApoE<sup>−/−</sup> Mice
title_fullStr	Consumption of Non-Nutritive Sweetener, Acesulfame Potassium Exacerbates Atherosclerosis through Dysregulation of Lipid Metabolism in ApoE<sup>−/−</sup> Mice
title_full_unstemmed	Consumption of Non-Nutritive Sweetener, Acesulfame Potassium Exacerbates Atherosclerosis through Dysregulation of Lipid Metabolism in ApoE<sup>−/−</sup> Mice
title_sort	consumption of non-nutritive sweetener, acesulfame potassium exacerbates atherosclerosis through dysregulation of lipid metabolism in apoe<sup>−/−</sup> mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e344a676d2c1416bb06f8054549ff4fb
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Consumption of Non-Nutritive Sweetener, Acesulfame Potassium Exacerbates Atherosclerosis through Dysregulation of Lipid Metabolism in ApoE<sup>−/−</sup> Mice

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