Comparison of risk factors for ischemic stroke and coronary events in a population-based cohort

Abstract Background Although coronary events (CE) and ischemic stroke share many risk factors, there are also some important differences. The aim of this paper was to assess the association of risk factors in relation to incident CE and ischemic stroke and to evaluate the heterogeneity in patterns o...

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Autores principales:	Iram Faqir Muhammad, Yan Borné, Suneela Zaigham, Martin Söderholm, Linda Johnson, Margaretha Persson, Olle Melander, Gunnar Engström
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Competing risk analysis Cardiovascular disease Epidemiology Ischemic stroke Risk factors Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/e34569ab30d64455b6401912680e161d
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spelling	oai:doaj.org-article:e34569ab30d64455b6401912680e161d2021-11-14T12:07:37ZComparison of risk factors for ischemic stroke and coronary events in a population-based cohort10.1186/s12872-021-02344-41471-2261https://doaj.org/article/e34569ab30d64455b6401912680e161d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12872-021-02344-4https://doaj.org/toc/1471-2261Abstract Background Although coronary events (CE) and ischemic stroke share many risk factors, there are also some important differences. The aim of this paper was to assess the association of risk factors in relation to incident CE and ischemic stroke and to evaluate the heterogeneity in patterns of risk factors between the two outcomes. Method Traditional risk factors and inflammatory markers associated with coronary events and ischemic stroke were measured in the Malmö Diet and Cancer Cohort (MDCS, n = 26 519), where a total of 2270 incident ischemic stroke and 3087 incident CE occurred during a mean follow up time 19 ± 6 years, and in relation to inflammatory markers in the cardiovascular sub-cohort (MDC-CV, n = 4795). Cox regression analysis was used to obtain hazard ratios. A modified Lunn-McNeil competing risk analysis was conducted to assess the significance of any differences in risk profiles of these outcomes. Results Most cardiovascular risk factors were associated both with incident CE and ischemic stroke. However, current smoking, ApoB, low ApoA1, male sex and education level of ≤ 9 years of schooling were preferentially associated with CE compared to ischemic stroke. Conversely, age showed a stronger association with ischemic stroke than with CE. Conclusion CE and ischemic stroke have broadly similar risk factors profiles. However, there are some important differential associations, as well as substantial differences in the magnitude of the association. These could reflect the distinct biology of atherogenesis in different vascular beds. The difference in the determinants highlights the importance of looking at CE and ischemic stroke, two manifestations of cardiovascular disease, separately.Iram Faqir MuhammadYan BornéSuneela ZaighamMartin SöderholmLinda JohnsonMargaretha PerssonOlle MelanderGunnar EngströmBMCarticleCompeting risk analysisCardiovascular diseaseEpidemiologyIschemic strokeRisk factorsDiseases of the circulatory (Cardiovascular) systemRC666-701ENBMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Competing risk analysis Cardiovascular disease Epidemiology Ischemic stroke Risk factors Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Competing risk analysis Cardiovascular disease Epidemiology Ischemic stroke Risk factors Diseases of the circulatory (Cardiovascular) system RC666-701 Iram Faqir Muhammad Yan Borné Suneela Zaigham Martin Söderholm Linda Johnson Margaretha Persson Olle Melander Gunnar Engström Comparison of risk factors for ischemic stroke and coronary events in a population-based cohort
description	Abstract Background Although coronary events (CE) and ischemic stroke share many risk factors, there are also some important differences. The aim of this paper was to assess the association of risk factors in relation to incident CE and ischemic stroke and to evaluate the heterogeneity in patterns of risk factors between the two outcomes. Method Traditional risk factors and inflammatory markers associated with coronary events and ischemic stroke were measured in the Malmö Diet and Cancer Cohort (MDCS, n = 26 519), where a total of 2270 incident ischemic stroke and 3087 incident CE occurred during a mean follow up time 19 ± 6 years, and in relation to inflammatory markers in the cardiovascular sub-cohort (MDC-CV, n = 4795). Cox regression analysis was used to obtain hazard ratios. A modified Lunn-McNeil competing risk analysis was conducted to assess the significance of any differences in risk profiles of these outcomes. Results Most cardiovascular risk factors were associated both with incident CE and ischemic stroke. However, current smoking, ApoB, low ApoA1, male sex and education level of ≤ 9 years of schooling were preferentially associated with CE compared to ischemic stroke. Conversely, age showed a stronger association with ischemic stroke than with CE. Conclusion CE and ischemic stroke have broadly similar risk factors profiles. However, there are some important differential associations, as well as substantial differences in the magnitude of the association. These could reflect the distinct biology of atherogenesis in different vascular beds. The difference in the determinants highlights the importance of looking at CE and ischemic stroke, two manifestations of cardiovascular disease, separately.
format	article
author	Iram Faqir Muhammad Yan Borné Suneela Zaigham Martin Söderholm Linda Johnson Margaretha Persson Olle Melander Gunnar Engström
author_facet	Iram Faqir Muhammad Yan Borné Suneela Zaigham Martin Söderholm Linda Johnson Margaretha Persson Olle Melander Gunnar Engström
author_sort	Iram Faqir Muhammad
title	Comparison of risk factors for ischemic stroke and coronary events in a population-based cohort
title_short	Comparison of risk factors for ischemic stroke and coronary events in a population-based cohort
title_full	Comparison of risk factors for ischemic stroke and coronary events in a population-based cohort
title_fullStr	Comparison of risk factors for ischemic stroke and coronary events in a population-based cohort
title_full_unstemmed	Comparison of risk factors for ischemic stroke and coronary events in a population-based cohort
title_sort	comparison of risk factors for ischemic stroke and coronary events in a population-based cohort
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e34569ab30d64455b6401912680e161d
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Comparison of risk factors for ischemic stroke and coronary events in a population-based cohort

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