Correlation between family history and characteristics of breast cancer

Abstract Family history is a major risk factor for breast cancer; approximately 5–10% cases of breast cancer are associated with a family history. Herein, we investigated the link between family history and breast cancer features to elucidate the importance of family history in the diagnosis and tre...

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Autores principales:	Lei Liu, Xiaomeng Hao, Zian Song, Xiangcheng Zhi, Sheng Zhang, Jin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3477b7fff154c2188800a22282d0d2a
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spelling	oai:doaj.org-article:e3477b7fff154c2188800a22282d0d2a2021-12-02T13:17:41ZCorrelation between family history and characteristics of breast cancer10.1038/s41598-021-85899-82045-2322https://doaj.org/article/e3477b7fff154c2188800a22282d0d2a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85899-8https://doaj.org/toc/2045-2322Abstract Family history is a major risk factor for breast cancer; approximately 5–10% cases of breast cancer are associated with a family history. Herein, we investigated the link between family history and breast cancer features to elucidate the importance of family history in the diagnosis and treatment of breast cancer. Data from 10,549 patients with breast cancer were collected from 2014 to 2017. Detailed information about the family history of the patients including the degree and number of relatives affected and the types of cancer was recorded. The tumors were pathologically and clinically classified based on the stage, grade, ER, PR, HER2, Ki-67 status, and subtypes, according to standard guidelines. Data were analyzed using χ2 test and multiple logistic regression. Patients with a family history of other cancer types were significantly older at diagnosis than patients with a family history of breast/ovarian cancer (p = 0.002) and those without a family history of cancer (p < 0.001). Patients without a family history of cancer were typically diagnosed at a later stage, including high frequency in N2 (p = 0.035) and TNM stage III (p = 0.015). Compared with patients with second-/third-degree relatives, those with first-degree relatives having breast/ovarian cancer had a higher median age (54.1, p < 0.001) at diagnosis and showed more advanced disease. No significant difference was found between ER, PR, and HER2 status in patients with and without a family history of cancer. Family history of breast cancer can influence the cancer characteristics of the patients at diagnosis, especially patient age, tumor stage, and grade.Lei LiuXiaomeng HaoZian SongXiangcheng ZhiSheng ZhangJin ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lei Liu Xiaomeng Hao Zian Song Xiangcheng Zhi Sheng Zhang Jin Zhang Correlation between family history and characteristics of breast cancer
description	Abstract Family history is a major risk factor for breast cancer; approximately 5–10% cases of breast cancer are associated with a family history. Herein, we investigated the link between family history and breast cancer features to elucidate the importance of family history in the diagnosis and treatment of breast cancer. Data from 10,549 patients with breast cancer were collected from 2014 to 2017. Detailed information about the family history of the patients including the degree and number of relatives affected and the types of cancer was recorded. The tumors were pathologically and clinically classified based on the stage, grade, ER, PR, HER2, Ki-67 status, and subtypes, according to standard guidelines. Data were analyzed using χ2 test and multiple logistic regression. Patients with a family history of other cancer types were significantly older at diagnosis than patients with a family history of breast/ovarian cancer (p = 0.002) and those without a family history of cancer (p < 0.001). Patients without a family history of cancer were typically diagnosed at a later stage, including high frequency in N2 (p = 0.035) and TNM stage III (p = 0.015). Compared with patients with second-/third-degree relatives, those with first-degree relatives having breast/ovarian cancer had a higher median age (54.1, p < 0.001) at diagnosis and showed more advanced disease. No significant difference was found between ER, PR, and HER2 status in patients with and without a family history of cancer. Family history of breast cancer can influence the cancer characteristics of the patients at diagnosis, especially patient age, tumor stage, and grade.
format	article
author	Lei Liu Xiaomeng Hao Zian Song Xiangcheng Zhi Sheng Zhang Jin Zhang
author_facet	Lei Liu Xiaomeng Hao Zian Song Xiangcheng Zhi Sheng Zhang Jin Zhang
author_sort	Lei Liu
title	Correlation between family history and characteristics of breast cancer
title_short	Correlation between family history and characteristics of breast cancer
title_full	Correlation between family history and characteristics of breast cancer
title_fullStr	Correlation between family history and characteristics of breast cancer
title_full_unstemmed	Correlation between family history and characteristics of breast cancer
title_sort	correlation between family history and characteristics of breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e3477b7fff154c2188800a22282d0d2a
work_keys_str_mv	AT leiliu correlationbetweenfamilyhistoryandcharacteristicsofbreastcancer AT xiaomenghao correlationbetweenfamilyhistoryandcharacteristicsofbreastcancer AT ziansong correlationbetweenfamilyhistoryandcharacteristicsofbreastcancer AT xiangchengzhi correlationbetweenfamilyhistoryandcharacteristicsofbreastcancer AT shengzhang correlationbetweenfamilyhistoryandcharacteristicsofbreastcancer AT jinzhang correlationbetweenfamilyhistoryandcharacteristicsofbreastcancer
_version_	1718393361431265280

Correlation between family history and characteristics of breast cancer

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