On the Road to Strain-Resolved Comparative Metagenomics

ABSTRACT Metagenomics has transformed microbiology, but its potential has not been fully expressed yet. From computational methods for digging deeper into metagenomes to study designs for addressing specific hypotheses, the Segata Lab is pursuing an integrative metagenomic approach to describe and m...

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Autor principal:	Nicola Segata
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	metagenomics human microbiome computational biology comparative microbial genomics strain profiling Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/e348b9ad645f41b4a6e7b69583d28e78
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spelling	oai:doaj.org-article:e348b9ad645f41b4a6e7b69583d28e782021-12-02T19:47:34ZOn the Road to Strain-Resolved Comparative Metagenomics10.1128/mSystems.00190-172379-5077https://doaj.org/article/e348b9ad645f41b4a6e7b69583d28e782018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00190-17https://doaj.org/toc/2379-5077ABSTRACT Metagenomics has transformed microbiology, but its potential has not been fully expressed yet. From computational methods for digging deeper into metagenomes to study designs for addressing specific hypotheses, the Segata Lab is pursuing an integrative metagenomic approach to describe and model human-associated microbial communities as collections of strains. Linking strain variants to host phenotypes and performing cultivation-free population genomics require large cohorts and meta-analysis strategies to synthesize available cohorts but can revolutionize our understanding of the personalized host-microbiome interface which is at the base of human health.Nicola SegataAmerican Society for Microbiologyarticlemetagenomicshuman microbiomecomputational biologycomparative microbial genomicsstrain profilingMicrobiologyQR1-502ENmSystems, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	metagenomics human microbiome computational biology comparative microbial genomics strain profiling Microbiology QR1-502
spellingShingle	metagenomics human microbiome computational biology comparative microbial genomics strain profiling Microbiology QR1-502 Nicola Segata On the Road to Strain-Resolved Comparative Metagenomics
description	ABSTRACT Metagenomics has transformed microbiology, but its potential has not been fully expressed yet. From computational methods for digging deeper into metagenomes to study designs for addressing specific hypotheses, the Segata Lab is pursuing an integrative metagenomic approach to describe and model human-associated microbial communities as collections of strains. Linking strain variants to host phenotypes and performing cultivation-free population genomics require large cohorts and meta-analysis strategies to synthesize available cohorts but can revolutionize our understanding of the personalized host-microbiome interface which is at the base of human health.
format	article
author	Nicola Segata
author_facet	Nicola Segata
author_sort	Nicola Segata
title	On the Road to Strain-Resolved Comparative Metagenomics
title_short	On the Road to Strain-Resolved Comparative Metagenomics
title_full	On the Road to Strain-Resolved Comparative Metagenomics
title_fullStr	On the Road to Strain-Resolved Comparative Metagenomics
title_full_unstemmed	On the Road to Strain-Resolved Comparative Metagenomics
title_sort	on the road to strain-resolved comparative metagenomics
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/e348b9ad645f41b4a6e7b69583d28e78
work_keys_str_mv	AT nicolasegata ontheroadtostrainresolvedcomparativemetagenomics
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On the Road to Strain-Resolved Comparative Metagenomics

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