Evaluation of potential drug interactions in hospital admission

Introduction: In clinical practice, drugs association is common and can lead to drug interactions (MI), which can lead to an avoidable adverse events that may need a for pharmaceutical intervention. Objective: The objective of this study is to identify and evaluate the drug interactions present on...

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Autores principales:	Jackeline L. Santos, Luana R. Spalla, Selma R. Castilho
Formato:	article
Lenguaje:	EN PT
Publicado:	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde 2020
Materias:	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e34a937a5d5a4571b101b7a3029c18cc
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spelling	oai:doaj.org-article:e34a937a5d5a4571b101b7a3029c18cc2021-11-28T02:45:56ZEvaluation of potential drug interactions in hospital admission10.30968/rbfhss.2019.101.03842179-59242316-7750https://doaj.org/article/e34a937a5d5a4571b101b7a3029c18cc2020-03-01T00:00:00Zhttps://www.rbfhss.org.br/sbrafh/article/view/384https://doaj.org/toc/2179-5924https://doaj.org/toc/2316-7750 Introduction: In clinical practice, drugs association is common and can lead to drug interactions (MI), which can lead to an avoidable adverse events that may need a for pharmaceutical intervention. Objective: The objective of this study is to identify and evaluate the drug interactions present on prescriptions of patients at the adult medical clinic of a hospital in Rio de Janeiro, at admission moment. Method: Cross-sectional study involving the analysis of information through the database (e-sus). Interactions were classified according to the Micromedex database. Results: A total of 177 prescriptions were evaluated. The main underlying disease was the neoplasias (36.16%), and the main cause of hospitalization was pain (8.5%). Of the prescriptions evaluated, 81.93% had some potential MI. A total of 180 types of MI were identified, representing 600 IM. Considering the degree of severity, 60% (358) were classified as severe MI, 38% (229) moderate, 1% (7) low and contraindicated. The most prevalent drug involved in MI was dipyrone (43.8%). The most frequent severe MI was between Dipirona + Enoxaparin (9.4%). Among moderate MI, Dipirone + Captopril (14.8%) was the most frequent and among the low ones, Furosemide + Hydralazine (42.9%). The contraindicated MI appeared in a similar way with 16.7% each. According to the scientific evidence found, serious MI had mostly reasonable documentation (59.5%), while the moderate ones had the majority of documentation classified as good (48.9%). Conclusion: In this context it is reasonable to consider that the pharmaceutical analysis of prescription at the patient admission may contribute to preventing drug-related adverse events. Jackeline L. SantosLuana R. SpallaSelma R. CastilhoSociedade Brasileira de Farmácia Hospitalar e Serviços de SaúdearticlePublic aspects of medicineRA1-1270Pharmacy and materia medicaRS1-441Therapeutics. PharmacologyRM1-950ENPTRevista Brasileira de Farmácia Hospitalar e Serviços de Saúde, Vol 10, Iss 1 (2020)
institution	DOAJ
collection	DOAJ
language	EN PT
topic	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950
spellingShingle	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950 Jackeline L. Santos Luana R. Spalla Selma R. Castilho Evaluation of potential drug interactions in hospital admission
description	Introduction: In clinical practice, drugs association is common and can lead to drug interactions (MI), which can lead to an avoidable adverse events that may need a for pharmaceutical intervention. Objective: The objective of this study is to identify and evaluate the drug interactions present on prescriptions of patients at the adult medical clinic of a hospital in Rio de Janeiro, at admission moment. Method: Cross-sectional study involving the analysis of information through the database (e-sus). Interactions were classified according to the Micromedex database. Results: A total of 177 prescriptions were evaluated. The main underlying disease was the neoplasias (36.16%), and the main cause of hospitalization was pain (8.5%). Of the prescriptions evaluated, 81.93% had some potential MI. A total of 180 types of MI were identified, representing 600 IM. Considering the degree of severity, 60% (358) were classified as severe MI, 38% (229) moderate, 1% (7) low and contraindicated. The most prevalent drug involved in MI was dipyrone (43.8%). The most frequent severe MI was between Dipirona + Enoxaparin (9.4%). Among moderate MI, Dipirone + Captopril (14.8%) was the most frequent and among the low ones, Furosemide + Hydralazine (42.9%). The contraindicated MI appeared in a similar way with 16.7% each. According to the scientific evidence found, serious MI had mostly reasonable documentation (59.5%), while the moderate ones had the majority of documentation classified as good (48.9%). Conclusion: In this context it is reasonable to consider that the pharmaceutical analysis of prescription at the patient admission may contribute to preventing drug-related adverse events.
format	article
author	Jackeline L. Santos Luana R. Spalla Selma R. Castilho
author_facet	Jackeline L. Santos Luana R. Spalla Selma R. Castilho
author_sort	Jackeline L. Santos
title	Evaluation of potential drug interactions in hospital admission
title_short	Evaluation of potential drug interactions in hospital admission
title_full	Evaluation of potential drug interactions in hospital admission
title_fullStr	Evaluation of potential drug interactions in hospital admission
title_full_unstemmed	Evaluation of potential drug interactions in hospital admission
title_sort	evaluation of potential drug interactions in hospital admission
publisher	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde
publishDate	2020
url	https://doaj.org/article/e34a937a5d5a4571b101b7a3029c18cc
work_keys_str_mv	AT jackelinelsantos evaluationofpotentialdruginteractionsinhospitaladmission AT luanarspalla evaluationofpotentialdruginteractionsinhospitaladmission AT selmarcastilho evaluationofpotentialdruginteractionsinhospitaladmission
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Evaluation of potential drug interactions in hospital admission

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