Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression

Post-transcriptional control of RNA is important in health and disease. Here, the authors show that the RNA-binding protein Quaking guides pre-mRNA splicing and transcript abundance during monocyte to macrophage differentiation, and that Quaking depletion impairs pro-atherogenic foam cell formation.

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Autores principales:	Ruben G. de Bruin, Lily Shiue, Jurriën Prins, Hetty C. de Boer, Anjana Singh, W. Samuel Fagg, Janine M. van Gils, Jacques M. G. J. Duijs, Sol Katzman, Adriaan O. Kraaijeveld, Stefan Böhringer, Wai Y. Leung, Szymon M. Kielbasa, John P. Donahue, Patrick H.J. van der Zande, Rick Sijbom, Carla M. A. van Alem, Ilze Bot, Cees van Kooten, J. Wouter Jukema, Hilde Van Esch, Ton J. Rabelink, Hilal Kazan, Erik A. L. Biessen, Manuel Ares Jr., Anton Jan van Zonneveld, Eric P. van der Veer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e34ae01b9e3449c1bdf812e5f403f63e
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spelling	oai:doaj.org-article:e34ae01b9e3449c1bdf812e5f403f63e2021-12-02T14:39:12ZQuaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression10.1038/ncomms108462041-1723https://doaj.org/article/e34ae01b9e3449c1bdf812e5f403f63e2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10846https://doaj.org/toc/2041-1723Post-transcriptional control of RNA is important in health and disease. Here, the authors show that the RNA-binding protein Quaking guides pre-mRNA splicing and transcript abundance during monocyte to macrophage differentiation, and that Quaking depletion impairs pro-atherogenic foam cell formation.Ruben G. de BruinLily ShiueJurriën PrinsHetty C. de BoerAnjana SinghW. Samuel FaggJanine M. van GilsJacques M. G. J. DuijsSol KatzmanAdriaan O. KraaijeveldStefan BöhringerWai Y. LeungSzymon M. KielbasaJohn P. DonahuePatrick H.J. van der ZandeRick SijbomCarla M. A. van AlemIlze BotCees van KootenJ. Wouter JukemaHilde Van EschTon J. RabelinkHilal KazanErik A. L. BiessenManuel Ares Jr.Anton Jan van ZonneveldEric P. van der VeerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-20 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruben G. de Bruin Lily Shiue Jurriën Prins Hetty C. de Boer Anjana Singh W. Samuel Fagg Janine M. van Gils Jacques M. G. J. Duijs Sol Katzman Adriaan O. Kraaijeveld Stefan Böhringer Wai Y. Leung Szymon M. Kielbasa John P. Donahue Patrick H.J. van der Zande Rick Sijbom Carla M. A. van Alem Ilze Bot Cees van Kooten J. Wouter Jukema Hilde Van Esch Ton J. Rabelink Hilal Kazan Erik A. L. Biessen Manuel Ares Jr. Anton Jan van Zonneveld Eric P. van der Veer Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression
description	Post-transcriptional control of RNA is important in health and disease. Here, the authors show that the RNA-binding protein Quaking guides pre-mRNA splicing and transcript abundance during monocyte to macrophage differentiation, and that Quaking depletion impairs pro-atherogenic foam cell formation.
format	article
author	Ruben G. de Bruin Lily Shiue Jurriën Prins Hetty C. de Boer Anjana Singh W. Samuel Fagg Janine M. van Gils Jacques M. G. J. Duijs Sol Katzman Adriaan O. Kraaijeveld Stefan Böhringer Wai Y. Leung Szymon M. Kielbasa John P. Donahue Patrick H.J. van der Zande Rick Sijbom Carla M. A. van Alem Ilze Bot Cees van Kooten J. Wouter Jukema Hilde Van Esch Ton J. Rabelink Hilal Kazan Erik A. L. Biessen Manuel Ares Jr. Anton Jan van Zonneveld Eric P. van der Veer
author_facet	Ruben G. de Bruin Lily Shiue Jurriën Prins Hetty C. de Boer Anjana Singh W. Samuel Fagg Janine M. van Gils Jacques M. G. J. Duijs Sol Katzman Adriaan O. Kraaijeveld Stefan Böhringer Wai Y. Leung Szymon M. Kielbasa John P. Donahue Patrick H.J. van der Zande Rick Sijbom Carla M. A. van Alem Ilze Bot Cees van Kooten J. Wouter Jukema Hilde Van Esch Ton J. Rabelink Hilal Kazan Erik A. L. Biessen Manuel Ares Jr. Anton Jan van Zonneveld Eric P. van der Veer
author_sort	Ruben G. de Bruin
title	Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression
title_short	Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression
title_full	Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression
title_fullStr	Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression
title_full_unstemmed	Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression
title_sort	quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mrna splicing and gene expression
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e34ae01b9e3449c1bdf812e5f403f63e
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Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression

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