Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice

GPRASP2 plays a role in trafficking of GPCRs and mutations in this gene have been linked to neurodevelopmental disorders. Here the authors study the role of Gprasp2 in the CNS and show that it regulates the surface availability of mGluR5 receptors and that knockout mice for this protein show autisti...

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Autores principales:	Mohamed Edfawy, Joana R. Guedes, Marta I. Pereira, Mariana Laranjo, Mário J. Carvalho, Xian Gao, Pedro A. Ferreira, Gladys Caldeira, Lara O. Franco, Dongqing Wang, Ana Luisa Cardoso, Guoping Feng, Ana Luisa Carvalho, João Peça
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e34c7220e13b45b1be4e855d23adeb92
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spelling	oai:doaj.org-article:e34c7220e13b45b1be4e855d23adeb922021-12-02T16:57:31ZAbnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice10.1038/s41467-019-09382-92041-1723https://doaj.org/article/e34c7220e13b45b1be4e855d23adeb922019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09382-9https://doaj.org/toc/2041-1723GPRASP2 plays a role in trafficking of GPCRs and mutations in this gene have been linked to neurodevelopmental disorders. Here the authors study the role of Gprasp2 in the CNS and show that it regulates the surface availability of mGluR5 receptors and that knockout mice for this protein show autistic-like behavioural abnormalities.Mohamed EdfawyJoana R. GuedesMarta I. PereiraMariana LaranjoMário J. CarvalhoXian GaoPedro A. FerreiraGladys CaldeiraLara O. FrancoDongqing WangAna Luisa CardosoGuoping FengAna Luisa CarvalhoJoão PeçaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mohamed Edfawy Joana R. Guedes Marta I. Pereira Mariana Laranjo Mário J. Carvalho Xian Gao Pedro A. Ferreira Gladys Caldeira Lara O. Franco Dongqing Wang Ana Luisa Cardoso Guoping Feng Ana Luisa Carvalho João Peça Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
description	GPRASP2 plays a role in trafficking of GPCRs and mutations in this gene have been linked to neurodevelopmental disorders. Here the authors study the role of Gprasp2 in the CNS and show that it regulates the surface availability of mGluR5 receptors and that knockout mice for this protein show autistic-like behavioural abnormalities.
format	article
author	Mohamed Edfawy Joana R. Guedes Marta I. Pereira Mariana Laranjo Mário J. Carvalho Xian Gao Pedro A. Ferreira Gladys Caldeira Lara O. Franco Dongqing Wang Ana Luisa Cardoso Guoping Feng Ana Luisa Carvalho João Peça
author_facet	Mohamed Edfawy Joana R. Guedes Marta I. Pereira Mariana Laranjo Mário J. Carvalho Xian Gao Pedro A. Ferreira Gladys Caldeira Lara O. Franco Dongqing Wang Ana Luisa Cardoso Guoping Feng Ana Luisa Carvalho João Peça
author_sort	Mohamed Edfawy
title	Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
title_short	Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
title_full	Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
title_fullStr	Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
title_full_unstemmed	Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
title_sort	abnormal mglur-mediated synaptic plasticity and autism-like behaviours in gprasp2 mutant mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e34c7220e13b45b1be4e855d23adeb92
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Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice

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