Clinical characteristics of optic neuritis phenotypes in a 3-year follow-up Chinese cohort

Abstract To evaluate the clinical characteristics of optic neuritis (ON) with different phenotypes. This prospective study recruited patients with new-onset ON between January 2015 and March 2017 who were followed-up for 3 years. They were divided into the myelin oligodendrocyte glycoprotein-seropos...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chaoyi Feng, Qian Chen, Guixian Zhao, Zhenxin Li, Weimin Chen, Yan Sha, Xinghuai Sun, Min Wang, Guohong Tian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e35438e4c0ae42dab6011eaa227f6384
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e35438e4c0ae42dab6011eaa227f6384
record_format	dspace
spelling	oai:doaj.org-article:e35438e4c0ae42dab6011eaa227f63842021-12-02T16:14:09ZClinical characteristics of optic neuritis phenotypes in a 3-year follow-up Chinese cohort10.1038/s41598-021-93976-12045-2322https://doaj.org/article/e35438e4c0ae42dab6011eaa227f63842021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93976-1https://doaj.org/toc/2045-2322Abstract To evaluate the clinical characteristics of optic neuritis (ON) with different phenotypes. This prospective study recruited patients with new-onset ON between January 2015 and March 2017 who were followed-up for 3 years. They were divided into the myelin oligodendrocyte glycoprotein-seropositive (MOG-ON), aquaporin-4-seropositive (AQP4-ON), and double-seronegative (seronegative-ON) groups, and their clinical characteristics and imaging findings were evaluated and compared. Two-hundred-eighty patients (405 eyes) were included (MOG-ON: n = 57, 20.4%; AQP4-ON: n = 98, 35.0%; seronegative-ON: n = 125, 44.6%). The proportion of eyes with best-corrected visual acuity > 20/25 at the 3-year follow-up was similar between the MOG-ON and seronegative-ON groups; the proportion in both groups was higher than that in the AQP4-ON group (p < 0.001). Relapse rates were higher in the MOG-ON and AQP4-ON groups than in the seronegative-ON group (p < 0.001). Average retinal nerve fiber layer (RNFL) thickness at 3 years was similar between the MOG-ON and AQP4-ON groups (63.41 ± 13.39 and 59.40 ± 11.46 μm, p = 0.476) but both were thinner than the seronegative-ON group (74.06 ± 11.14 μm, p < 0.001). Macular ganglion cell-inner plexiform layer (GCIPL) revealed the same pattern. Despite RNFL and GCIPL thinning, the MOG-ON group’s outcome was as favorable as that of the seronegative-ON group, whereas the AQP4-ON group showed unsatisfactory results.Chaoyi FengQian ChenGuixian ZhaoZhenxin LiWeimin ChenYan ShaXinghuai SunMin WangGuohong TianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chaoyi Feng Qian Chen Guixian Zhao Zhenxin Li Weimin Chen Yan Sha Xinghuai Sun Min Wang Guohong Tian Clinical characteristics of optic neuritis phenotypes in a 3-year follow-up Chinese cohort
description	Abstract To evaluate the clinical characteristics of optic neuritis (ON) with different phenotypes. This prospective study recruited patients with new-onset ON between January 2015 and March 2017 who were followed-up for 3 years. They were divided into the myelin oligodendrocyte glycoprotein-seropositive (MOG-ON), aquaporin-4-seropositive (AQP4-ON), and double-seronegative (seronegative-ON) groups, and their clinical characteristics and imaging findings were evaluated and compared. Two-hundred-eighty patients (405 eyes) were included (MOG-ON: n = 57, 20.4%; AQP4-ON: n = 98, 35.0%; seronegative-ON: n = 125, 44.6%). The proportion of eyes with best-corrected visual acuity > 20/25 at the 3-year follow-up was similar between the MOG-ON and seronegative-ON groups; the proportion in both groups was higher than that in the AQP4-ON group (p < 0.001). Relapse rates were higher in the MOG-ON and AQP4-ON groups than in the seronegative-ON group (p < 0.001). Average retinal nerve fiber layer (RNFL) thickness at 3 years was similar between the MOG-ON and AQP4-ON groups (63.41 ± 13.39 and 59.40 ± 11.46 μm, p = 0.476) but both were thinner than the seronegative-ON group (74.06 ± 11.14 μm, p < 0.001). Macular ganglion cell-inner plexiform layer (GCIPL) revealed the same pattern. Despite RNFL and GCIPL thinning, the MOG-ON group’s outcome was as favorable as that of the seronegative-ON group, whereas the AQP4-ON group showed unsatisfactory results.
format	article
author	Chaoyi Feng Qian Chen Guixian Zhao Zhenxin Li Weimin Chen Yan Sha Xinghuai Sun Min Wang Guohong Tian
author_facet	Chaoyi Feng Qian Chen Guixian Zhao Zhenxin Li Weimin Chen Yan Sha Xinghuai Sun Min Wang Guohong Tian
author_sort	Chaoyi Feng
title	Clinical characteristics of optic neuritis phenotypes in a 3-year follow-up Chinese cohort
title_short	Clinical characteristics of optic neuritis phenotypes in a 3-year follow-up Chinese cohort
title_full	Clinical characteristics of optic neuritis phenotypes in a 3-year follow-up Chinese cohort
title_fullStr	Clinical characteristics of optic neuritis phenotypes in a 3-year follow-up Chinese cohort
title_full_unstemmed	Clinical characteristics of optic neuritis phenotypes in a 3-year follow-up Chinese cohort
title_sort	clinical characteristics of optic neuritis phenotypes in a 3-year follow-up chinese cohort
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e35438e4c0ae42dab6011eaa227f6384
work_keys_str_mv	AT chaoyifeng clinicalcharacteristicsofopticneuritisphenotypesina3yearfollowupchinesecohort AT qianchen clinicalcharacteristicsofopticneuritisphenotypesina3yearfollowupchinesecohort AT guixianzhao clinicalcharacteristicsofopticneuritisphenotypesina3yearfollowupchinesecohort AT zhenxinli clinicalcharacteristicsofopticneuritisphenotypesina3yearfollowupchinesecohort AT weiminchen clinicalcharacteristicsofopticneuritisphenotypesina3yearfollowupchinesecohort AT yansha clinicalcharacteristicsofopticneuritisphenotypesina3yearfollowupchinesecohort AT xinghuaisun clinicalcharacteristicsofopticneuritisphenotypesina3yearfollowupchinesecohort AT minwang clinicalcharacteristicsofopticneuritisphenotypesina3yearfollowupchinesecohort AT guohongtian clinicalcharacteristicsofopticneuritisphenotypesina3yearfollowupchinesecohort
_version_	1718384381541744640

Clinical characteristics of optic neuritis phenotypes in a 3-year follow-up Chinese cohort

Ejemplares similares