BK virus infection and outcome following kidney transplantation in childhood

Abstract BK virus associated nephropathy (BKN) is an important cause of kidney allograft failure. In a cohort of paediatric kidney transplant recipients, we aimed to understand the incidence and clinical outcome associated with BKN, as well as identify risk factors for BKN and BK viraemia developmen...

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Autores principales:	James McCaffrey, Vijesh J. Bhute, Mohan Shenoy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e35bc8c518134281a40d24d1424b62d8
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spelling	oai:doaj.org-article:e35bc8c518134281a40d24d1424b62d82021-12-02T13:57:38ZBK virus infection and outcome following kidney transplantation in childhood10.1038/s41598-021-82160-02045-2322https://doaj.org/article/e35bc8c518134281a40d24d1424b62d82021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82160-0https://doaj.org/toc/2045-2322Abstract BK virus associated nephropathy (BKN) is an important cause of kidney allograft failure. In a cohort of paediatric kidney transplant recipients, we aimed to understand the incidence and clinical outcome associated with BKN, as well as identify risk factors for BKN and BK viraemia development. We retrospectively analysed all patients who received a kidney transplant and received follow up care in our centre between 2009–2019. Among 106 patients included in the study (mean follow up 4.5 years), 32/106 (30.2%) patients experienced BK viraemia. The incidence of BKN was 7/106 (6.6%). The median time of BK viraemia development post-transplant was 279.5 days compared to 90.0 days for BKN. Development of BKN was associated with younger age at transplantation (p = 0.013). Development of BK viraemia was associated with negative recipient serology for cytomegalovirus (CMV) at time of transplantation (p = 0.012) and a higher net level of immunosuppression (p = 0.039). There was no difference in graft function at latest follow up between those who experienced BKN and those without BKN. This study demonstrates that BK virus infection is associated with younger age at transplantation, CMV negative recipient serostatus and higher levels of immunosuppression. Judicious monitoring of BK viraemia in paediatric transplant recipients, coupled with timely clinical intervention can result in similar long-term outcomes for BKN patients compared to controls.James McCaffreyVijesh J. BhuteMohan ShenoyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q James McCaffrey Vijesh J. Bhute Mohan Shenoy BK virus infection and outcome following kidney transplantation in childhood
description	Abstract BK virus associated nephropathy (BKN) is an important cause of kidney allograft failure. In a cohort of paediatric kidney transplant recipients, we aimed to understand the incidence and clinical outcome associated with BKN, as well as identify risk factors for BKN and BK viraemia development. We retrospectively analysed all patients who received a kidney transplant and received follow up care in our centre between 2009–2019. Among 106 patients included in the study (mean follow up 4.5 years), 32/106 (30.2%) patients experienced BK viraemia. The incidence of BKN was 7/106 (6.6%). The median time of BK viraemia development post-transplant was 279.5 days compared to 90.0 days for BKN. Development of BKN was associated with younger age at transplantation (p = 0.013). Development of BK viraemia was associated with negative recipient serology for cytomegalovirus (CMV) at time of transplantation (p = 0.012) and a higher net level of immunosuppression (p = 0.039). There was no difference in graft function at latest follow up between those who experienced BKN and those without BKN. This study demonstrates that BK virus infection is associated with younger age at transplantation, CMV negative recipient serostatus and higher levels of immunosuppression. Judicious monitoring of BK viraemia in paediatric transplant recipients, coupled with timely clinical intervention can result in similar long-term outcomes for BKN patients compared to controls.
format	article
author	James McCaffrey Vijesh J. Bhute Mohan Shenoy
author_facet	James McCaffrey Vijesh J. Bhute Mohan Shenoy
author_sort	James McCaffrey
title	BK virus infection and outcome following kidney transplantation in childhood
title_short	BK virus infection and outcome following kidney transplantation in childhood
title_full	BK virus infection and outcome following kidney transplantation in childhood
title_fullStr	BK virus infection and outcome following kidney transplantation in childhood
title_full_unstemmed	BK virus infection and outcome following kidney transplantation in childhood
title_sort	bk virus infection and outcome following kidney transplantation in childhood
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e35bc8c518134281a40d24d1424b62d8
work_keys_str_mv	AT jamesmccaffrey bkvirusinfectionandoutcomefollowingkidneytransplantationinchildhood AT vijeshjbhute bkvirusinfectionandoutcomefollowingkidneytransplantationinchildhood AT mohanshenoy bkvirusinfectionandoutcomefollowingkidneytransplantationinchildhood
_version_	1718392293121064960

BK virus infection and outcome following kidney transplantation in childhood

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