Clinical features and outcomes of bowel perforation in primary pediatric gastrointestinal lymphoma

Abstract Background Whether surgery can improve the prognosis of patients with primary pediatric gastrointestinal lymphoma (PPGL) who experienced bowel perforation remains controversial. This study aimed to evaluate the prognosis of such patients. Methods Nine patients pathologically diagnosed with...

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Autores principales:	Jiayu Yan, Yanlong Duan, Tingting Liu, Jianlin Guo, Chunhui Peng, Wenbo Pang, Dan Zhang, Yun Peng, Yajun Chen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Primary gastrointestinal lymphoma Children Bowel perforation Surgery Outcome Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/e35c896f62e74832b380b08664036347
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spelling	oai:doaj.org-article:e35c896f62e74832b380b086640363472021-12-05T12:21:09ZClinical features and outcomes of bowel perforation in primary pediatric gastrointestinal lymphoma10.1186/s12887-021-02944-11471-2431https://doaj.org/article/e35c896f62e74832b380b086640363472021-12-01T00:00:00Zhttps://doi.org/10.1186/s12887-021-02944-1https://doaj.org/toc/1471-2431Abstract Background Whether surgery can improve the prognosis of patients with primary pediatric gastrointestinal lymphoma (PPGL) who experienced bowel perforation remains controversial. This study aimed to evaluate the prognosis of such patients. Methods Nine patients pathologically diagnosed with PPGL who experienced perforation at our center between January 2010 and December 2020 were enrolled and divided into two groups: those with perforation during (n = 4) and before (n = 5) chemotherapy. Their medical records were reviewed, and long-term follow-up was conducted by telephone in February 2021. Results All patients with perforation during chemotherapy were diagnosed with PPGL in the outpatient department. The mean time from outpatient visit to chemotherapy was 17.3 ± 6.1 days. Two patients experienced perforation during the first chemotherapy regimen and received conservative treatment, while the others developed perforation after multiple chemotherapy regimens and underwent surgery. All of the patients received regular chemotherapy and survived for a mean follow-up time of 3.8 ± 1.9 years. No patient with perforation before chemotherapy had a definite diagnosis in the outpatient department. Among these patients, 4 experienced perforation and underwent surgery, of whom 3 developed perforation-related complications and died; the other recurred after chemotherapy. Only the patient who received conservative treatment was diagnosed with PPGL before chemotherapy, received regular chemotherapy, and survived without a recurrence for 1.0 year. Conclusion Prompt diagnosis and chemotherapy improve the prognosis of PPGL. Surgery does not affect the prognosis of patients with perforation during chemotherapy but may accelerate disease progression in patients with perforation before chemotherapy.Jiayu YanYanlong DuanTingting LiuJianlin GuoChunhui PengWenbo PangDan ZhangYun PengYajun ChenBMCarticlePrimary gastrointestinal lymphomaChildrenBowel perforationSurgeryOutcomePediatricsRJ1-570ENBMC Pediatrics, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Primary gastrointestinal lymphoma Children Bowel perforation Surgery Outcome Pediatrics RJ1-570
spellingShingle	Primary gastrointestinal lymphoma Children Bowel perforation Surgery Outcome Pediatrics RJ1-570 Jiayu Yan Yanlong Duan Tingting Liu Jianlin Guo Chunhui Peng Wenbo Pang Dan Zhang Yun Peng Yajun Chen Clinical features and outcomes of bowel perforation in primary pediatric gastrointestinal lymphoma
description	Abstract Background Whether surgery can improve the prognosis of patients with primary pediatric gastrointestinal lymphoma (PPGL) who experienced bowel perforation remains controversial. This study aimed to evaluate the prognosis of such patients. Methods Nine patients pathologically diagnosed with PPGL who experienced perforation at our center between January 2010 and December 2020 were enrolled and divided into two groups: those with perforation during (n = 4) and before (n = 5) chemotherapy. Their medical records were reviewed, and long-term follow-up was conducted by telephone in February 2021. Results All patients with perforation during chemotherapy were diagnosed with PPGL in the outpatient department. The mean time from outpatient visit to chemotherapy was 17.3 ± 6.1 days. Two patients experienced perforation during the first chemotherapy regimen and received conservative treatment, while the others developed perforation after multiple chemotherapy regimens and underwent surgery. All of the patients received regular chemotherapy and survived for a mean follow-up time of 3.8 ± 1.9 years. No patient with perforation before chemotherapy had a definite diagnosis in the outpatient department. Among these patients, 4 experienced perforation and underwent surgery, of whom 3 developed perforation-related complications and died; the other recurred after chemotherapy. Only the patient who received conservative treatment was diagnosed with PPGL before chemotherapy, received regular chemotherapy, and survived without a recurrence for 1.0 year. Conclusion Prompt diagnosis and chemotherapy improve the prognosis of PPGL. Surgery does not affect the prognosis of patients with perforation during chemotherapy but may accelerate disease progression in patients with perforation before chemotherapy.
format	article
author	Jiayu Yan Yanlong Duan Tingting Liu Jianlin Guo Chunhui Peng Wenbo Pang Dan Zhang Yun Peng Yajun Chen
author_facet	Jiayu Yan Yanlong Duan Tingting Liu Jianlin Guo Chunhui Peng Wenbo Pang Dan Zhang Yun Peng Yajun Chen
author_sort	Jiayu Yan
title	Clinical features and outcomes of bowel perforation in primary pediatric gastrointestinal lymphoma
title_short	Clinical features and outcomes of bowel perforation in primary pediatric gastrointestinal lymphoma
title_full	Clinical features and outcomes of bowel perforation in primary pediatric gastrointestinal lymphoma
title_fullStr	Clinical features and outcomes of bowel perforation in primary pediatric gastrointestinal lymphoma
title_full_unstemmed	Clinical features and outcomes of bowel perforation in primary pediatric gastrointestinal lymphoma
title_sort	clinical features and outcomes of bowel perforation in primary pediatric gastrointestinal lymphoma
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e35c896f62e74832b380b08664036347
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Clinical features and outcomes of bowel perforation in primary pediatric gastrointestinal lymphoma

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