Effect of adapter duration on repetition suppression in inferior temporal cortex

Abstract Many inferior temporal (IT) cortical neurons reduce their response when a stimulus is repeated. Proposed mechanisms underlying this repetition suppression range from “fatigue” to top-down expectations of repetition. Here we examine a prediction from simple fatigue-based models of adaptation...

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Autores principales:	Pradeep Kuravi, Rufin Vogels
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e35d443f129c4b0481c39a6cd5b5292d
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spelling	oai:doaj.org-article:e35d443f129c4b0481c39a6cd5b5292d2021-12-02T12:32:05ZEffect of adapter duration on repetition suppression in inferior temporal cortex10.1038/s41598-017-03172-32045-2322https://doaj.org/article/e35d443f129c4b0481c39a6cd5b5292d2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03172-3https://doaj.org/toc/2045-2322Abstract Many inferior temporal (IT) cortical neurons reduce their response when a stimulus is repeated. Proposed mechanisms underlying this repetition suppression range from “fatigue” to top-down expectations of repetition. Here we examine a prediction from simple fatigue-based models of adaptation: prolonging adapter duration will increase the adapter response, leading to more repetition suppression. To test this, we varied adapter duration from 300 to 3000 ms, keeping the test stimulus duration constant. We observed no effect of adapter duration on repetition suppression when averaging responses across the test presentation. This was not because of a ceiling effect, since repeated presentations of a short adapter increased repetition suppression. Examination of test stimulus responses showed increased repetition suppression with longer adapter durations during the initial response phase, which reversed at a later phase. Across neurons, we found that the degree of repetition suppression covaried with the ratio of the response during the initial transient and later sustained phase of the response during the long adapter presentation, suggesting overlapping mechanisms that underlie adaptation during the adapter and the delayed test. We propose a fatigue-based account in which fatigue increases non-linearly with adapter duration to explain these unexpected findings.Pradeep KuraviRufin VogelsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pradeep Kuravi Rufin Vogels Effect of adapter duration on repetition suppression in inferior temporal cortex
description	Abstract Many inferior temporal (IT) cortical neurons reduce their response when a stimulus is repeated. Proposed mechanisms underlying this repetition suppression range from “fatigue” to top-down expectations of repetition. Here we examine a prediction from simple fatigue-based models of adaptation: prolonging adapter duration will increase the adapter response, leading to more repetition suppression. To test this, we varied adapter duration from 300 to 3000 ms, keeping the test stimulus duration constant. We observed no effect of adapter duration on repetition suppression when averaging responses across the test presentation. This was not because of a ceiling effect, since repeated presentations of a short adapter increased repetition suppression. Examination of test stimulus responses showed increased repetition suppression with longer adapter durations during the initial response phase, which reversed at a later phase. Across neurons, we found that the degree of repetition suppression covaried with the ratio of the response during the initial transient and later sustained phase of the response during the long adapter presentation, suggesting overlapping mechanisms that underlie adaptation during the adapter and the delayed test. We propose a fatigue-based account in which fatigue increases non-linearly with adapter duration to explain these unexpected findings.
format	article
author	Pradeep Kuravi Rufin Vogels
author_facet	Pradeep Kuravi Rufin Vogels
author_sort	Pradeep Kuravi
title	Effect of adapter duration on repetition suppression in inferior temporal cortex
title_short	Effect of adapter duration on repetition suppression in inferior temporal cortex
title_full	Effect of adapter duration on repetition suppression in inferior temporal cortex
title_fullStr	Effect of adapter duration on repetition suppression in inferior temporal cortex
title_full_unstemmed	Effect of adapter duration on repetition suppression in inferior temporal cortex
title_sort	effect of adapter duration on repetition suppression in inferior temporal cortex
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e35d443f129c4b0481c39a6cd5b5292d
work_keys_str_mv	AT pradeepkuravi effectofadapterdurationonrepetitionsuppressionininferiortemporalcortex AT rufinvogels effectofadapterdurationonrepetitionsuppressionininferiortemporalcortex
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Effect of adapter duration on repetition suppression in inferior temporal cortex

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