Clonal competition within complex evolutionary hierarchies shapes AML over time

Clonal evolution and heterogeneity has strong implications for treatment response in acute myeloid leukemia. Here, the authors use patient derived in vivo modelling to highlight the complex clonal and evolutionary dynamics underpinning acute myeloid leukemia progression.

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Autores principales:	Carl Sandén, Henrik Lilljebjörn, Christina Orsmark Pietras, Rasmus Henningsson, Karim H. Saba, Niklas Landberg, Hanna Thorsson, Sofia von Palffy, Pablo Peña-Martinez, Carl Högberg, Marianne Rissler, David Gisselsson, Vladimir Lazarevic, Gunnar Juliusson, Helena Ågerstam, Thoas Fioretos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e35f9025834f4b02be68bf3c32279eaa
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spelling	oai:doaj.org-article:e35f9025834f4b02be68bf3c32279eaa2021-12-02T14:40:40ZClonal competition within complex evolutionary hierarchies shapes AML over time10.1038/s41467-019-14106-02041-1723https://doaj.org/article/e35f9025834f4b02be68bf3c32279eaa2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14106-0https://doaj.org/toc/2041-1723Clonal evolution and heterogeneity has strong implications for treatment response in acute myeloid leukemia. Here, the authors use patient derived in vivo modelling to highlight the complex clonal and evolutionary dynamics underpinning acute myeloid leukemia progression.Carl SandénHenrik LilljebjörnChristina Orsmark PietrasRasmus HenningssonKarim H. SabaNiklas LandbergHanna ThorssonSofia von PalffyPablo Peña-MartinezCarl HögbergMarianne RisslerDavid GisselssonVladimir LazarevicGunnar JuliussonHelena ÅgerstamThoas FioretosNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carl Sandén Henrik Lilljebjörn Christina Orsmark Pietras Rasmus Henningsson Karim H. Saba Niklas Landberg Hanna Thorsson Sofia von Palffy Pablo Peña-Martinez Carl Högberg Marianne Rissler David Gisselsson Vladimir Lazarevic Gunnar Juliusson Helena Ågerstam Thoas Fioretos Clonal competition within complex evolutionary hierarchies shapes AML over time
description	Clonal evolution and heterogeneity has strong implications for treatment response in acute myeloid leukemia. Here, the authors use patient derived in vivo modelling to highlight the complex clonal and evolutionary dynamics underpinning acute myeloid leukemia progression.
format	article
author	Carl Sandén Henrik Lilljebjörn Christina Orsmark Pietras Rasmus Henningsson Karim H. Saba Niklas Landberg Hanna Thorsson Sofia von Palffy Pablo Peña-Martinez Carl Högberg Marianne Rissler David Gisselsson Vladimir Lazarevic Gunnar Juliusson Helena Ågerstam Thoas Fioretos
author_facet	Carl Sandén Henrik Lilljebjörn Christina Orsmark Pietras Rasmus Henningsson Karim H. Saba Niklas Landberg Hanna Thorsson Sofia von Palffy Pablo Peña-Martinez Carl Högberg Marianne Rissler David Gisselsson Vladimir Lazarevic Gunnar Juliusson Helena Ågerstam Thoas Fioretos
author_sort	Carl Sandén
title	Clonal competition within complex evolutionary hierarchies shapes AML over time
title_short	Clonal competition within complex evolutionary hierarchies shapes AML over time
title_full	Clonal competition within complex evolutionary hierarchies shapes AML over time
title_fullStr	Clonal competition within complex evolutionary hierarchies shapes AML over time
title_full_unstemmed	Clonal competition within complex evolutionary hierarchies shapes AML over time
title_sort	clonal competition within complex evolutionary hierarchies shapes aml over time
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e35f9025834f4b02be68bf3c32279eaa
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Clonal competition within complex evolutionary hierarchies shapes AML over time

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