Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study

Abstract Background Although red blood cells (RBC) transfusion is known to be significantly associated with biochemical recurrence in patients undergoing open prostatectomy, its influence on biochemical recurrence after robot-assisted laparoscopic radical prostatectomy remains unclear. Therefore, th...

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Autores principales:	Jiwon Han, Young-Tae Jeon, Jung-Hee Ryu, Ah-Young Oh, Hwanik Kim, Yu Kyung Bae, Chang-Hoon Koo
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Biochemical recurrence Red blood cell transfusion Robot-assisted laparoscopic radical prostatectomy Prostate cancer Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/e361644c2a374831a482945a6f3d7449
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spelling	oai:doaj.org-article:e361644c2a374831a482945a6f3d74492021-11-21T12:31:00ZBlood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study10.1186/s12894-021-00926-01471-2490https://doaj.org/article/e361644c2a374831a482945a6f3d74492021-11-01T00:00:00Zhttps://doi.org/10.1186/s12894-021-00926-0https://doaj.org/toc/1471-2490Abstract Background Although red blood cells (RBC) transfusion is known to be significantly associated with biochemical recurrence in patients undergoing open prostatectomy, its influence on biochemical recurrence after robot-assisted laparoscopic radical prostatectomy remains unclear. Therefore, this study aimed to validate the effect of RBC transfusion on the 5-year biochemical recurrence in patients undergoing robot-assisted laparoscopic radical prostatectomy. Methods This study retrospectively analyzed the medical records of patients who underwent robot-assisted laparoscopic radical prostatectomy at single tertiary academic hospital between October 2007 and December 2014. Univariate and multivariate Cox proportional hazard regression analysis was performed to identify any potential variables associated with 5-year biochemical recurrence. Results A total of 1311 patients were included in the final analysis. Of these, 30 patients (2.3%) were transfused with RBC either during robot-assisted laparoscopic radical prostatectomy or during their hospital stay, which corresponded to 5-year biochemical recurrence of 15.7%. Multivariate Cox proportional hazard regression analysis showed that RBC transfusion had no influence on the 5-year biochemical recurrence. Variables including pathologic T stage (Hazard ratio [HR] 3.5, 95% confidence interval [CI] 2.4–5.1 p < 0.001), N stage (HR 2.3, 95% CI 1.5–3.7, p < 0.001), Gleason score (HR 2.4, 95% CI 1.8–3.2, p < 0.001), and surgical margin (HR 2.0, 95% CI 1.5–2.8, p < 0.001) were independently associated with the 5-year biochemical recurrence. Conclusions RBC transfusion had no significant influence on the 5-year biochemical recurrence in patients undergoing robot-assisted laparoscopic radical prostatectomy.Jiwon HanYoung-Tae JeonJung-Hee RyuAh-Young OhHwanik KimYu Kyung BaeChang-Hoon KooBMCarticleBiochemical recurrenceRed blood cell transfusionRobot-assisted laparoscopic radical prostatectomyProstate cancerDiseases of the genitourinary system. UrologyRC870-923ENBMC Urology, Vol 21, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biochemical recurrence Red blood cell transfusion Robot-assisted laparoscopic radical prostatectomy Prostate cancer Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Biochemical recurrence Red blood cell transfusion Robot-assisted laparoscopic radical prostatectomy Prostate cancer Diseases of the genitourinary system. Urology RC870-923 Jiwon Han Young-Tae Jeon Jung-Hee Ryu Ah-Young Oh Hwanik Kim Yu Kyung Bae Chang-Hoon Koo Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study
description	Abstract Background Although red blood cells (RBC) transfusion is known to be significantly associated with biochemical recurrence in patients undergoing open prostatectomy, its influence on biochemical recurrence after robot-assisted laparoscopic radical prostatectomy remains unclear. Therefore, this study aimed to validate the effect of RBC transfusion on the 5-year biochemical recurrence in patients undergoing robot-assisted laparoscopic radical prostatectomy. Methods This study retrospectively analyzed the medical records of patients who underwent robot-assisted laparoscopic radical prostatectomy at single tertiary academic hospital between October 2007 and December 2014. Univariate and multivariate Cox proportional hazard regression analysis was performed to identify any potential variables associated with 5-year biochemical recurrence. Results A total of 1311 patients were included in the final analysis. Of these, 30 patients (2.3%) were transfused with RBC either during robot-assisted laparoscopic radical prostatectomy or during their hospital stay, which corresponded to 5-year biochemical recurrence of 15.7%. Multivariate Cox proportional hazard regression analysis showed that RBC transfusion had no influence on the 5-year biochemical recurrence. Variables including pathologic T stage (Hazard ratio [HR] 3.5, 95% confidence interval [CI] 2.4–5.1 p < 0.001), N stage (HR 2.3, 95% CI 1.5–3.7, p < 0.001), Gleason score (HR 2.4, 95% CI 1.8–3.2, p < 0.001), and surgical margin (HR 2.0, 95% CI 1.5–2.8, p < 0.001) were independently associated with the 5-year biochemical recurrence. Conclusions RBC transfusion had no significant influence on the 5-year biochemical recurrence in patients undergoing robot-assisted laparoscopic radical prostatectomy.
format	article
author	Jiwon Han Young-Tae Jeon Jung-Hee Ryu Ah-Young Oh Hwanik Kim Yu Kyung Bae Chang-Hoon Koo
author_facet	Jiwon Han Young-Tae Jeon Jung-Hee Ryu Ah-Young Oh Hwanik Kim Yu Kyung Bae Chang-Hoon Koo
author_sort	Jiwon Han
title	Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study
title_short	Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study
title_full	Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study
title_fullStr	Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study
title_full_unstemmed	Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study
title_sort	blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e361644c2a374831a482945a6f3d7449
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Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study

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