Predicting the Prognosis of Esophageal Adenocarcinoma by a Pyroptosis-Related Gene Signature

Esophageal adenocarcinoma (EAC) is a highly malignant type of digestive tract cancers with a poor prognosis despite therapeutic advances. Pyroptosis is an inflammatory form of programmed cell death, whereas the role of pyroptosis in EAC remains largely unknown. Herein, we identified a pyroptosis-rel...

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Autores principales:	Ruijie Zeng, Shujie Huang, Xinqi Qiu, Zewei Zhuo, Huihuan Wu, Lei Jiang, Weihong Sha, Hao Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pyroptosis esophageal adenocarcinoma prognosis methylation tumor microenvironment Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e362e1bb0ed648df8d4fa22a2dfb43e5
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spelling	oai:doaj.org-article:e362e1bb0ed648df8d4fa22a2dfb43e52021-11-18T07:34:45ZPredicting the Prognosis of Esophageal Adenocarcinoma by a Pyroptosis-Related Gene Signature1663-981210.3389/fphar.2021.767187https://doaj.org/article/e362e1bb0ed648df8d4fa22a2dfb43e52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.767187/fullhttps://doaj.org/toc/1663-9812Esophageal adenocarcinoma (EAC) is a highly malignant type of digestive tract cancers with a poor prognosis despite therapeutic advances. Pyroptosis is an inflammatory form of programmed cell death, whereas the role of pyroptosis in EAC remains largely unknown. Herein, we identified a pyroptosis-related five-gene signature that was significantly correlated with the survival of EAC patients in The Cancer Genome Atlas (TCGA) cohort and an independent validation dataset. In addition, a nomogram based on the signature was constructed with novel prognostic values. Moreover, the downregulation of GSDMB within the signature is notably correlated with enhanced DNA methylation. The pyroptosis-related signature might be related to the immune response and regulation of the tumor microenvironment. Several inhibitors including GDC-0879 and PD-0325901 are promising in reversing the altered differentially expressed genes in high-risk patients. Our findings provide insights into the involvement of pyroptosis in EAC progression and are promising in the risk assessment as well as the prognosis for EAC patients in clinical practice.Ruijie ZengRuijie ZengShujie HuangShujie HuangXinqi QiuZewei ZhuoHuihuan WuLei JiangWeihong ShaHao ChenFrontiers Media S.A.articlepyroptosisesophageal adenocarcinomaprognosismethylationtumor microenvironmentTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pyroptosis esophageal adenocarcinoma prognosis methylation tumor microenvironment Therapeutics. Pharmacology RM1-950
spellingShingle	pyroptosis esophageal adenocarcinoma prognosis methylation tumor microenvironment Therapeutics. Pharmacology RM1-950 Ruijie Zeng Ruijie Zeng Shujie Huang Shujie Huang Xinqi Qiu Zewei Zhuo Huihuan Wu Lei Jiang Weihong Sha Hao Chen Predicting the Prognosis of Esophageal Adenocarcinoma by a Pyroptosis-Related Gene Signature
description	Esophageal adenocarcinoma (EAC) is a highly malignant type of digestive tract cancers with a poor prognosis despite therapeutic advances. Pyroptosis is an inflammatory form of programmed cell death, whereas the role of pyroptosis in EAC remains largely unknown. Herein, we identified a pyroptosis-related five-gene signature that was significantly correlated with the survival of EAC patients in The Cancer Genome Atlas (TCGA) cohort and an independent validation dataset. In addition, a nomogram based on the signature was constructed with novel prognostic values. Moreover, the downregulation of GSDMB within the signature is notably correlated with enhanced DNA methylation. The pyroptosis-related signature might be related to the immune response and regulation of the tumor microenvironment. Several inhibitors including GDC-0879 and PD-0325901 are promising in reversing the altered differentially expressed genes in high-risk patients. Our findings provide insights into the involvement of pyroptosis in EAC progression and are promising in the risk assessment as well as the prognosis for EAC patients in clinical practice.
format	article
author	Ruijie Zeng Ruijie Zeng Shujie Huang Shujie Huang Xinqi Qiu Zewei Zhuo Huihuan Wu Lei Jiang Weihong Sha Hao Chen
author_facet	Ruijie Zeng Ruijie Zeng Shujie Huang Shujie Huang Xinqi Qiu Zewei Zhuo Huihuan Wu Lei Jiang Weihong Sha Hao Chen
author_sort	Ruijie Zeng
title	Predicting the Prognosis of Esophageal Adenocarcinoma by a Pyroptosis-Related Gene Signature
title_short	Predicting the Prognosis of Esophageal Adenocarcinoma by a Pyroptosis-Related Gene Signature
title_full	Predicting the Prognosis of Esophageal Adenocarcinoma by a Pyroptosis-Related Gene Signature
title_fullStr	Predicting the Prognosis of Esophageal Adenocarcinoma by a Pyroptosis-Related Gene Signature
title_full_unstemmed	Predicting the Prognosis of Esophageal Adenocarcinoma by a Pyroptosis-Related Gene Signature
title_sort	predicting the prognosis of esophageal adenocarcinoma by a pyroptosis-related gene signature
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e362e1bb0ed648df8d4fa22a2dfb43e5
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Predicting the Prognosis of Esophageal Adenocarcinoma by a Pyroptosis-Related Gene Signature

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