Pretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients

Abstract We aimed to assess whether brain volumes may affect the results of deep brain stimulation (DBS) in patients with Parkinson’s disease (PD). Eighty-one consecutive patients with PD (male:female 40:41), treated with DBS between June 2012 and December 2017, were enrolled. Total and regional bra...

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Autores principales:	Younghee Yim, Sang Joon Kim, Seung Chai Jung, Ho Sung Kim, Choong Gon Choi, Jung Kyo Lee, Chong Sik Lee, Seung Hyun Lee, Woo Hyun Shim, E.-N. Cheong, Seong-Cheol Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e365024dbef8406998320450d885d909
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spelling	oai:doaj.org-article:e365024dbef8406998320450d885d9092021-12-02T13:34:10ZPretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients10.1038/s41598-020-79138-92045-2322https://doaj.org/article/e365024dbef8406998320450d885d9092020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79138-9https://doaj.org/toc/2045-2322Abstract We aimed to assess whether brain volumes may affect the results of deep brain stimulation (DBS) in patients with Parkinson’s disease (PD). Eighty-one consecutive patients with PD (male:female 40:41), treated with DBS between June 2012 and December 2017, were enrolled. Total and regional brain volumes were measured using automated brain volumetry (NeuroQuant). The Unified Parkinson Disease Rating Scale motor score quotient was used to assess changes in clinical outcome and compare the preoperative regional brain volume in patients categorized into the higher motor improvement and lower motor improvement groups based on changes in the postoperative scores. The study groups showed significant volume differences in multiple brain areas. In the higher motor improvement group, the anterior cingulate and right thalamus showed high volumes after false discovery rate (FDR) correction. In the lower motor improvement group, the left caudate, paracentral, right primary sensory and left primary motor cortex showed high volume, but no area showed high volumes after FDR correction. Our data suggest that the effectiveness of DBS in patients with PD may be affected by decreased brain volume in different areas, including the cingulate gyrus and thalamus. Preoperative volumetry could help predict outcomes in patients with PD undergoing DBS.Younghee YimSang Joon KimSeung Chai JungHo Sung KimChoong Gon ChoiJung Kyo LeeChong Sik LeeSeung Hyun LeeWoo Hyun ShimE.-N. CheongSeong-Cheol ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Younghee Yim Sang Joon Kim Seung Chai Jung Ho Sung Kim Choong Gon Choi Jung Kyo Lee Chong Sik Lee Seung Hyun Lee Woo Hyun Shim E.-N. Cheong Seong-Cheol Park Pretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients
description	Abstract We aimed to assess whether brain volumes may affect the results of deep brain stimulation (DBS) in patients with Parkinson’s disease (PD). Eighty-one consecutive patients with PD (male:female 40:41), treated with DBS between June 2012 and December 2017, were enrolled. Total and regional brain volumes were measured using automated brain volumetry (NeuroQuant). The Unified Parkinson Disease Rating Scale motor score quotient was used to assess changes in clinical outcome and compare the preoperative regional brain volume in patients categorized into the higher motor improvement and lower motor improvement groups based on changes in the postoperative scores. The study groups showed significant volume differences in multiple brain areas. In the higher motor improvement group, the anterior cingulate and right thalamus showed high volumes after false discovery rate (FDR) correction. In the lower motor improvement group, the left caudate, paracentral, right primary sensory and left primary motor cortex showed high volume, but no area showed high volumes after FDR correction. Our data suggest that the effectiveness of DBS in patients with PD may be affected by decreased brain volume in different areas, including the cingulate gyrus and thalamus. Preoperative volumetry could help predict outcomes in patients with PD undergoing DBS.
format	article
author	Younghee Yim Sang Joon Kim Seung Chai Jung Ho Sung Kim Choong Gon Choi Jung Kyo Lee Chong Sik Lee Seung Hyun Lee Woo Hyun Shim E.-N. Cheong Seong-Cheol Park
author_facet	Younghee Yim Sang Joon Kim Seung Chai Jung Ho Sung Kim Choong Gon Choi Jung Kyo Lee Chong Sik Lee Seung Hyun Lee Woo Hyun Shim E.-N. Cheong Seong-Cheol Park
author_sort	Younghee Yim
title	Pretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients
title_short	Pretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients
title_full	Pretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients
title_fullStr	Pretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients
title_full_unstemmed	Pretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients
title_sort	pretreatment brain volumes can affect the effectiveness of deep brain stimulation in parkinson's disease patients
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e365024dbef8406998320450d885d909
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Pretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients

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