Quantitation of the ROS production in plasma and radiation treatments of biotargets

Abstract Medical treatment utilizing non-thermal plasma is based on the production of reactive oxygen species (ROS) and their interactions with biomatters. On the basis of empirical data from practices, plasma treatment has been planned with regard to the setup of a plasma generator’s parameters, in...

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Autores principales:	Wan-Ook Ji, Min-Ho Lee, Gon-Ho Kim, Eun-Hee Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e36b7311630141c0a300dcda4f006dc6
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spelling	oai:doaj.org-article:e36b7311630141c0a300dcda4f006dc62021-12-02T13:35:12ZQuantitation of the ROS production in plasma and radiation treatments of biotargets10.1038/s41598-019-56160-02045-2322https://doaj.org/article/e36b7311630141c0a300dcda4f006dc62019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56160-0https://doaj.org/toc/2045-2322Abstract Medical treatment utilizing non-thermal plasma is based on the production of reactive oxygen species (ROS) and their interactions with biomatters. On the basis of empirical data from practices, plasma treatment has been planned with regard to the setup of a plasma generator’s parameters, including gas combination, gas-flow rate, and applied voltage. In this study, we quantitated plasma treatment in terms of the plasma dose on the target matter, which can be contrasted with the radiation dose to targets under radiation exposure. We measured the OH radical production in cell culture medium and intracellular ROS production from plasma treatment in comparison with those from X-ray exposure. The clonogenic cell deaths from plasma and X-ray exposures were also compared. In plasma treatment, the clonogenic cell death was better predicted by intracellular ROS production rather than by medium OH production.Wan-Ook JiMin-Ho LeeGon-Ho KimEun-Hee KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wan-Ook Ji Min-Ho Lee Gon-Ho Kim Eun-Hee Kim Quantitation of the ROS production in plasma and radiation treatments of biotargets
description	Abstract Medical treatment utilizing non-thermal plasma is based on the production of reactive oxygen species (ROS) and their interactions with biomatters. On the basis of empirical data from practices, plasma treatment has been planned with regard to the setup of a plasma generator’s parameters, including gas combination, gas-flow rate, and applied voltage. In this study, we quantitated plasma treatment in terms of the plasma dose on the target matter, which can be contrasted with the radiation dose to targets under radiation exposure. We measured the OH radical production in cell culture medium and intracellular ROS production from plasma treatment in comparison with those from X-ray exposure. The clonogenic cell deaths from plasma and X-ray exposures were also compared. In plasma treatment, the clonogenic cell death was better predicted by intracellular ROS production rather than by medium OH production.
format	article
author	Wan-Ook Ji Min-Ho Lee Gon-Ho Kim Eun-Hee Kim
author_facet	Wan-Ook Ji Min-Ho Lee Gon-Ho Kim Eun-Hee Kim
author_sort	Wan-Ook Ji
title	Quantitation of the ROS production in plasma and radiation treatments of biotargets
title_short	Quantitation of the ROS production in plasma and radiation treatments of biotargets
title_full	Quantitation of the ROS production in plasma and radiation treatments of biotargets
title_fullStr	Quantitation of the ROS production in plasma and radiation treatments of biotargets
title_full_unstemmed	Quantitation of the ROS production in plasma and radiation treatments of biotargets
title_sort	quantitation of the ros production in plasma and radiation treatments of biotargets
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e36b7311630141c0a300dcda4f006dc6
work_keys_str_mv	AT wanookji quantitationoftherosproductioninplasmaandradiationtreatmentsofbiotargets AT minholee quantitationoftherosproductioninplasmaandradiationtreatmentsofbiotargets AT gonhokim quantitationoftherosproductioninplasmaandradiationtreatmentsofbiotargets AT eunheekim quantitationoftherosproductioninplasmaandradiationtreatmentsofbiotargets
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Quantitation of the ROS production in plasma and radiation treatments of biotargets

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