Oligomeric state of the ZIKV E protein defines protective immune responses

Many human antibodies that neutralize Zika virus recognize quaternary epitopes on the envelope (E) protein. Here, Metz et al. engineer stable recombinant homodimers of Zika virus E protein and show that it induces neutralizing antibodies in mice that recognize similar epitopes as human antibodies fr...

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Autores principales:	Stefan W. Metz, Ashlie Thomas, Alex Brackbill, John Forsberg, Michael J. Miley, Cesar A. Lopez, Helen M. Lazear, Shaomin Tian, Aravinda M. de Silva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e36de0074bf54f54a8a6e3c49a2d1323
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spelling	oai:doaj.org-article:e36de0074bf54f54a8a6e3c49a2d13232021-12-02T15:35:27ZOligomeric state of the ZIKV E protein defines protective immune responses10.1038/s41467-019-12677-62041-1723https://doaj.org/article/e36de0074bf54f54a8a6e3c49a2d13232019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12677-6https://doaj.org/toc/2041-1723Many human antibodies that neutralize Zika virus recognize quaternary epitopes on the envelope (E) protein. Here, Metz et al. engineer stable recombinant homodimers of Zika virus E protein and show that it induces neutralizing antibodies in mice that recognize similar epitopes as human antibodies from Zika infected people.Stefan W. MetzAshlie ThomasAlex BrackbillJohn ForsbergMichael J. MileyCesar A. LopezHelen M. LazearShaomin TianAravinda M. de SilvaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stefan W. Metz Ashlie Thomas Alex Brackbill John Forsberg Michael J. Miley Cesar A. Lopez Helen M. Lazear Shaomin Tian Aravinda M. de Silva Oligomeric state of the ZIKV E protein defines protective immune responses
description	Many human antibodies that neutralize Zika virus recognize quaternary epitopes on the envelope (E) protein. Here, Metz et al. engineer stable recombinant homodimers of Zika virus E protein and show that it induces neutralizing antibodies in mice that recognize similar epitopes as human antibodies from Zika infected people.
format	article
author	Stefan W. Metz Ashlie Thomas Alex Brackbill John Forsberg Michael J. Miley Cesar A. Lopez Helen M. Lazear Shaomin Tian Aravinda M. de Silva
author_facet	Stefan W. Metz Ashlie Thomas Alex Brackbill John Forsberg Michael J. Miley Cesar A. Lopez Helen M. Lazear Shaomin Tian Aravinda M. de Silva
author_sort	Stefan W. Metz
title	Oligomeric state of the ZIKV E protein defines protective immune responses
title_short	Oligomeric state of the ZIKV E protein defines protective immune responses
title_full	Oligomeric state of the ZIKV E protein defines protective immune responses
title_fullStr	Oligomeric state of the ZIKV E protein defines protective immune responses
title_full_unstemmed	Oligomeric state of the ZIKV E protein defines protective immune responses
title_sort	oligomeric state of the zikv e protein defines protective immune responses
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e36de0074bf54f54a8a6e3c49a2d1323
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Oligomeric state of the ZIKV E protein defines protective immune responses

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