A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

Amplification of PDGFRα is a common alteration in glioblastoma. In this study, the authors develop a genetically engineered mouse model of GBM based on autocrine, chronic stimulation of overexpressed PDGFR and discover Stathmin1 as an important PDGFRα regulated-protein involved in the response to vi...

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Autores principales: Hyun Jung Jun, Vicky A. Appleman, Hua-Jun Wu, Christopher M. Rose, Javier J. Pineda, Alan T. Yeo, Bethany Delcuze, Charlotte Lee, Aron Gyuris, Haihao Zhu, Steve Woolfenden, Agnieszka Bronisz, Ichiro Nakano, Ennio A. Chiocca, Roderick T. Bronson, Keith L. Ligon, Jann N. Sarkaria, Steve P. Gygi, Franziska Michor, Timothy J. Mitchison, Al Charest
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/e36e588f60e24fb6aa72e07d8947fc7d
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spelling oai:doaj.org-article:e36e588f60e24fb6aa72e07d8947fc7d2021-12-02T17:31:43ZA PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine10.1038/s41467-018-05036-42041-1723https://doaj.org/article/e36e588f60e24fb6aa72e07d8947fc7d2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05036-4https://doaj.org/toc/2041-1723Amplification of PDGFRα is a common alteration in glioblastoma. In this study, the authors develop a genetically engineered mouse model of GBM based on autocrine, chronic stimulation of overexpressed PDGFR and discover Stathmin1 as an important PDGFRα regulated-protein involved in the response to vinstabline.Hyun Jung JunVicky A. ApplemanHua-Jun WuChristopher M. RoseJavier J. PinedaAlan T. YeoBethany DelcuzeCharlotte LeeAron GyurisHaihao ZhuSteve WoolfendenAgnieszka BroniszIchiro NakanoEnnio A. ChioccaRoderick T. BronsonKeith L. LigonJann N. SarkariaSteve P. GygiFranziska MichorTimothy J. MitchisonAl CharestNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hyun Jung Jun
Vicky A. Appleman
Hua-Jun Wu
Christopher M. Rose
Javier J. Pineda
Alan T. Yeo
Bethany Delcuze
Charlotte Lee
Aron Gyuris
Haihao Zhu
Steve Woolfenden
Agnieszka Bronisz
Ichiro Nakano
Ennio A. Chiocca
Roderick T. Bronson
Keith L. Ligon
Jann N. Sarkaria
Steve P. Gygi
Franziska Michor
Timothy J. Mitchison
Al Charest
A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine
description Amplification of PDGFRα is a common alteration in glioblastoma. In this study, the authors develop a genetically engineered mouse model of GBM based on autocrine, chronic stimulation of overexpressed PDGFR and discover Stathmin1 as an important PDGFRα regulated-protein involved in the response to vinstabline.
format article
author Hyun Jung Jun
Vicky A. Appleman
Hua-Jun Wu
Christopher M. Rose
Javier J. Pineda
Alan T. Yeo
Bethany Delcuze
Charlotte Lee
Aron Gyuris
Haihao Zhu
Steve Woolfenden
Agnieszka Bronisz
Ichiro Nakano
Ennio A. Chiocca
Roderick T. Bronson
Keith L. Ligon
Jann N. Sarkaria
Steve P. Gygi
Franziska Michor
Timothy J. Mitchison
Al Charest
author_facet Hyun Jung Jun
Vicky A. Appleman
Hua-Jun Wu
Christopher M. Rose
Javier J. Pineda
Alan T. Yeo
Bethany Delcuze
Charlotte Lee
Aron Gyuris
Haihao Zhu
Steve Woolfenden
Agnieszka Bronisz
Ichiro Nakano
Ennio A. Chiocca
Roderick T. Bronson
Keith L. Ligon
Jann N. Sarkaria
Steve P. Gygi
Franziska Michor
Timothy J. Mitchison
Al Charest
author_sort Hyun Jung Jun
title A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine
title_short A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine
title_full A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine
title_fullStr A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine
title_full_unstemmed A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine
title_sort pdgfrα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/e36e588f60e24fb6aa72e07d8947fc7d
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