Neuronal Encoding of Self and Others’ Head Rotation in the Macaque Dorsal Prefrontal Cortex

Abstract Following gaze is a crucial skill, in primates, for understanding where and at what others are looking, and often requires head rotation. The neural basis underlying head rotation are deemed to overlap with the parieto-frontal attention/gaze-shift network. Here, we show that a set of neuron...

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Autores principales:	M. Lanzilotto, M. Gerbella, V. Perciavalle, C. Lucchetti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e36f9fd4f7b34031a61eae8eb583a16d
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spelling	oai:doaj.org-article:e36f9fd4f7b34031a61eae8eb583a16d2021-12-02T15:05:50ZNeuronal Encoding of Self and Others’ Head Rotation in the Macaque Dorsal Prefrontal Cortex10.1038/s41598-017-08936-52045-2322https://doaj.org/article/e36f9fd4f7b34031a61eae8eb583a16d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08936-5https://doaj.org/toc/2045-2322Abstract Following gaze is a crucial skill, in primates, for understanding where and at what others are looking, and often requires head rotation. The neural basis underlying head rotation are deemed to overlap with the parieto-frontal attention/gaze-shift network. Here, we show that a set of neurons in monkey’s Brodmann area 9/46dr (BA 9/46dr), which is involved in orienting processes and joint attention, becomes active during self head rotation and that the activity of these neurons cannot be accounted for by saccade-related activity (head-rotation neurons). Another set of BA 9/46dr neurons encodes head rotation performed by an observed agent facing the monkey (visually triggered neurons). Among these latter neurons, almost half exhibit the intriguing property of encoding both execution and observation of head rotation (mirror-like neurons). Finally, by means of neuronal tracing techniques, we showed that BA 9/46dr takes part into two distinct networks: a dorso/mesial network, playing a role in spatial head/gaze orientation, and a ventrolateral network, likely involved in processing social stimuli and mirroring others’ head. The overall results of this study provide a new, comprehensive picture of the role of BA 9/46dr in encoding self and others’ head rotation, likely playing a role in head-following behaviors.M. LanzilottoM. GerbellaV. PerciavalleC. LucchettiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Lanzilotto M. Gerbella V. Perciavalle C. Lucchetti Neuronal Encoding of Self and Others’ Head Rotation in the Macaque Dorsal Prefrontal Cortex
description	Abstract Following gaze is a crucial skill, in primates, for understanding where and at what others are looking, and often requires head rotation. The neural basis underlying head rotation are deemed to overlap with the parieto-frontal attention/gaze-shift network. Here, we show that a set of neurons in monkey’s Brodmann area 9/46dr (BA 9/46dr), which is involved in orienting processes and joint attention, becomes active during self head rotation and that the activity of these neurons cannot be accounted for by saccade-related activity (head-rotation neurons). Another set of BA 9/46dr neurons encodes head rotation performed by an observed agent facing the monkey (visually triggered neurons). Among these latter neurons, almost half exhibit the intriguing property of encoding both execution and observation of head rotation (mirror-like neurons). Finally, by means of neuronal tracing techniques, we showed that BA 9/46dr takes part into two distinct networks: a dorso/mesial network, playing a role in spatial head/gaze orientation, and a ventrolateral network, likely involved in processing social stimuli and mirroring others’ head. The overall results of this study provide a new, comprehensive picture of the role of BA 9/46dr in encoding self and others’ head rotation, likely playing a role in head-following behaviors.
format	article
author	M. Lanzilotto M. Gerbella V. Perciavalle C. Lucchetti
author_facet	M. Lanzilotto M. Gerbella V. Perciavalle C. Lucchetti
author_sort	M. Lanzilotto
title	Neuronal Encoding of Self and Others’ Head Rotation in the Macaque Dorsal Prefrontal Cortex
title_short	Neuronal Encoding of Self and Others’ Head Rotation in the Macaque Dorsal Prefrontal Cortex
title_full	Neuronal Encoding of Self and Others’ Head Rotation in the Macaque Dorsal Prefrontal Cortex
title_fullStr	Neuronal Encoding of Self and Others’ Head Rotation in the Macaque Dorsal Prefrontal Cortex
title_full_unstemmed	Neuronal Encoding of Self and Others’ Head Rotation in the Macaque Dorsal Prefrontal Cortex
title_sort	neuronal encoding of self and others’ head rotation in the macaque dorsal prefrontal cortex
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e36f9fd4f7b34031a61eae8eb583a16d
work_keys_str_mv	AT mlanzilotto neuronalencodingofselfandothersheadrotationinthemacaquedorsalprefrontalcortex AT mgerbella neuronalencodingofselfandothersheadrotationinthemacaquedorsalprefrontalcortex AT vperciavalle neuronalencodingofselfandothersheadrotationinthemacaquedorsalprefrontalcortex AT clucchetti neuronalencodingofselfandothersheadrotationinthemacaquedorsalprefrontalcortex
_version_	1718388676408377344

Neuronal Encoding of Self and Others’ Head Rotation in the Macaque Dorsal Prefrontal Cortex

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