Necroptosis mediates myofibre death in dystrophin-deficient mice

Muscular dystrophies are characterised by extensive myofibre cell death. Here Morgan et al. show that RIPK3-mediated necroptosis contributes to myofibre cell death in Duchenne muscular dystrophy, and that RIPK3 deletion protects dystrophic mice against myofibre degeneration.

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Auteurs principaux:	Jennifer E. Morgan, Alexandre Prola, Virginie Mariot, Veronica Pini, Jinhong Meng, Christophe Hourde, Julie Dumonceaux, Francesco Conti, Frederic Relaix, Francois-Jerôme Authier, Laurent Tiret, Francesco Muntoni, Maximilien Bencze
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e3702b52675e4cdd82568be2bf38a982
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spelling	oai:doaj.org-article:e3702b52675e4cdd82568be2bf38a9822021-12-02T14:40:30ZNecroptosis mediates myofibre death in dystrophin-deficient mice10.1038/s41467-018-06057-92041-1723https://doaj.org/article/e3702b52675e4cdd82568be2bf38a9822018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06057-9https://doaj.org/toc/2041-1723Muscular dystrophies are characterised by extensive myofibre cell death. Here Morgan et al. show that RIPK3-mediated necroptosis contributes to myofibre cell death in Duchenne muscular dystrophy, and that RIPK3 deletion protects dystrophic mice against myofibre degeneration.Jennifer E. MorganAlexandre ProlaVirginie MariotVeronica PiniJinhong MengChristophe HourdeJulie DumonceauxFrancesco ContiFrederic RelaixFrancois-Jerôme AuthierLaurent TiretFrancesco MuntoniMaximilien BenczeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer E. Morgan Alexandre Prola Virginie Mariot Veronica Pini Jinhong Meng Christophe Hourde Julie Dumonceaux Francesco Conti Frederic Relaix Francois-Jerôme Authier Laurent Tiret Francesco Muntoni Maximilien Bencze Necroptosis mediates myofibre death in dystrophin-deficient mice
description	Muscular dystrophies are characterised by extensive myofibre cell death. Here Morgan et al. show that RIPK3-mediated necroptosis contributes to myofibre cell death in Duchenne muscular dystrophy, and that RIPK3 deletion protects dystrophic mice against myofibre degeneration.
format	article
author	Jennifer E. Morgan Alexandre Prola Virginie Mariot Veronica Pini Jinhong Meng Christophe Hourde Julie Dumonceaux Francesco Conti Frederic Relaix Francois-Jerôme Authier Laurent Tiret Francesco Muntoni Maximilien Bencze
author_facet	Jennifer E. Morgan Alexandre Prola Virginie Mariot Veronica Pini Jinhong Meng Christophe Hourde Julie Dumonceaux Francesco Conti Frederic Relaix Francois-Jerôme Authier Laurent Tiret Francesco Muntoni Maximilien Bencze
author_sort	Jennifer E. Morgan
title	Necroptosis mediates myofibre death in dystrophin-deficient mice
title_short	Necroptosis mediates myofibre death in dystrophin-deficient mice
title_full	Necroptosis mediates myofibre death in dystrophin-deficient mice
title_fullStr	Necroptosis mediates myofibre death in dystrophin-deficient mice
title_full_unstemmed	Necroptosis mediates myofibre death in dystrophin-deficient mice
title_sort	necroptosis mediates myofibre death in dystrophin-deficient mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e3702b52675e4cdd82568be2bf38a982
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Necroptosis mediates myofibre death in dystrophin-deficient mice

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