Necroptosis mediates myofibre death in dystrophin-deficient mice

Muscular dystrophies are characterised by extensive myofibre cell death. Here Morgan et al. show that RIPK3-mediated necroptosis contributes to myofibre cell death in Duchenne muscular dystrophy, and that RIPK3 deletion protects dystrophic mice against myofibre degeneration.

Guardado en:

Detalles Bibliográficos
Autores principales:	Jennifer E. Morgan, Alexandre Prola, Virginie Mariot, Veronica Pini, Jinhong Meng, Christophe Hourde, Julie Dumonceaux, Francesco Conti, Frederic Relaix, Francois-Jerôme Authier, Laurent Tiret, Francesco Muntoni, Maximilien Bencze
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e3702b52675e4cdd82568be2bf38a982
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e3702b52675e4cdd82568be2bf38a982
record_format	dspace
spelling	oai:doaj.org-article:e3702b52675e4cdd82568be2bf38a9822021-12-02T14:40:30ZNecroptosis mediates myofibre death in dystrophin-deficient mice10.1038/s41467-018-06057-92041-1723https://doaj.org/article/e3702b52675e4cdd82568be2bf38a9822018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06057-9https://doaj.org/toc/2041-1723Muscular dystrophies are characterised by extensive myofibre cell death. Here Morgan et al. show that RIPK3-mediated necroptosis contributes to myofibre cell death in Duchenne muscular dystrophy, and that RIPK3 deletion protects dystrophic mice against myofibre degeneration.Jennifer E. MorganAlexandre ProlaVirginie MariotVeronica PiniJinhong MengChristophe HourdeJulie DumonceauxFrancesco ContiFrederic RelaixFrancois-Jerôme AuthierLaurent TiretFrancesco MuntoniMaximilien BenczeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer E. Morgan Alexandre Prola Virginie Mariot Veronica Pini Jinhong Meng Christophe Hourde Julie Dumonceaux Francesco Conti Frederic Relaix Francois-Jerôme Authier Laurent Tiret Francesco Muntoni Maximilien Bencze Necroptosis mediates myofibre death in dystrophin-deficient mice
description	Muscular dystrophies are characterised by extensive myofibre cell death. Here Morgan et al. show that RIPK3-mediated necroptosis contributes to myofibre cell death in Duchenne muscular dystrophy, and that RIPK3 deletion protects dystrophic mice against myofibre degeneration.
format	article
author	Jennifer E. Morgan Alexandre Prola Virginie Mariot Veronica Pini Jinhong Meng Christophe Hourde Julie Dumonceaux Francesco Conti Frederic Relaix Francois-Jerôme Authier Laurent Tiret Francesco Muntoni Maximilien Bencze
author_facet	Jennifer E. Morgan Alexandre Prola Virginie Mariot Veronica Pini Jinhong Meng Christophe Hourde Julie Dumonceaux Francesco Conti Frederic Relaix Francois-Jerôme Authier Laurent Tiret Francesco Muntoni Maximilien Bencze
author_sort	Jennifer E. Morgan
title	Necroptosis mediates myofibre death in dystrophin-deficient mice
title_short	Necroptosis mediates myofibre death in dystrophin-deficient mice
title_full	Necroptosis mediates myofibre death in dystrophin-deficient mice
title_fullStr	Necroptosis mediates myofibre death in dystrophin-deficient mice
title_full_unstemmed	Necroptosis mediates myofibre death in dystrophin-deficient mice
title_sort	necroptosis mediates myofibre death in dystrophin-deficient mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e3702b52675e4cdd82568be2bf38a982
work_keys_str_mv	AT jenniferemorgan necroptosismediatesmyofibredeathindystrophindeficientmice AT alexandreprola necroptosismediatesmyofibredeathindystrophindeficientmice AT virginiemariot necroptosismediatesmyofibredeathindystrophindeficientmice AT veronicapini necroptosismediatesmyofibredeathindystrophindeficientmice AT jinhongmeng necroptosismediatesmyofibredeathindystrophindeficientmice AT christophehourde necroptosismediatesmyofibredeathindystrophindeficientmice AT juliedumonceaux necroptosismediatesmyofibredeathindystrophindeficientmice AT francescoconti necroptosismediatesmyofibredeathindystrophindeficientmice AT fredericrelaix necroptosismediatesmyofibredeathindystrophindeficientmice AT francoisjeromeauthier necroptosismediatesmyofibredeathindystrophindeficientmice AT laurenttiret necroptosismediatesmyofibredeathindystrophindeficientmice AT francescomuntoni necroptosismediatesmyofibredeathindystrophindeficientmice AT maximilienbencze necroptosismediatesmyofibredeathindystrophindeficientmice
_version_	1718390269033840640

Necroptosis mediates myofibre death in dystrophin-deficient mice

Ejemplares similares