Necroptosis mediates myofibre death in dystrophin-deficient mice

Necroptosis mediates myofibre death in dystrophin-deficient mice

Muscular dystrophies are characterised by extensive myofibre cell death. Here Morgan et al. show that RIPK3-mediated necroptosis contributes to myofibre cell death in Duchenne muscular dystrophy, and that RIPK3 deletion protects dystrophic mice against myofibre degeneration.

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Bibliographic Details
Main Authors: Jennifer E. Morgan, Alexandre Prola, Virginie Mariot, Veronica Pini, Jinhong Meng, Christophe Hourde, Julie Dumonceaux, Francesco Conti, Frederic Relaix, Francois-Jerôme Authier, Laurent Tiret, Francesco Muntoni, Maximilien Bencze
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/e3702b52675e4cdd82568be2bf38a982
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Internet

https://doaj.org/article/e3702b52675e4cdd82568be2bf38a982

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