Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation

The optimal antithrombotic treatment in patients receiving oral anticoagulation undergoing percutaneous coronary intervention (PCI) has been a field of intensive research. Although triple antithrombotic therapy had been, until lately, the strategy of choice, recent evidence points to the superiority...

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Autores principales:	Despoina-Rafailia Benetou, Panayotis K Vlachakis, Charalampos Varlamos, Dimitrios Alexopoulos
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/e373f115d45b402495e5748cca5ec0cc
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spelling	oai:doaj.org-article:e373f115d45b402495e5748cca5ec0cc2021-12-04T16:04:31ZAntithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation10.15420/usc.2020.311758-390X1758-3896https://doaj.org/article/e373f115d45b402495e5748cca5ec0cc2021-05-01T00:00:00Zhttps://www.uscjournal.com/articleindex/usc.2020.31https://doaj.org/toc/1758-3896https://doaj.org/toc/1758-390XThe optimal antithrombotic treatment in patients receiving oral anticoagulation undergoing percutaneous coronary intervention (PCI) has been a field of intensive research. Although triple antithrombotic therapy had been, until lately, the strategy of choice, recent evidence points to the superiority of dual antithrombotic therapy regarding bleeding prevention, without significantly compromising efficacy. In the further challenging scenario of complex PCI, associated with a higher ischemic risk, the efficacy of an aspirin-free strategy, adopted shortly after the index event is under question, rendering decision-making a fairly difficult scenario for clinicians. Since patients with an indication for oral anticoagulation undergoing complex PCI are underrepresented in randomized trials, there are scarce data regarding the optimal treatment strategy in such patients. This review aims to analyze and compare different approaches regarding the type and duration of antithrombotic regimens, focusing on both safety and efficacy outcomes, as well as to discuss recent guidelines’ suggestions regarding the therapeutic approach in patients receiving oral anticoagulation undergoing PCI procedures of increased complexity.Despoina-Rafailia BenetouPanayotis K VlachakisCharalampos VarlamosDimitrios AlexopoulosRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENUS Cardiology Review , Vol 15, Iss , Pp - (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Despoina-Rafailia Benetou Panayotis K Vlachakis Charalampos Varlamos Dimitrios Alexopoulos Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation
description	The optimal antithrombotic treatment in patients receiving oral anticoagulation undergoing percutaneous coronary intervention (PCI) has been a field of intensive research. Although triple antithrombotic therapy had been, until lately, the strategy of choice, recent evidence points to the superiority of dual antithrombotic therapy regarding bleeding prevention, without significantly compromising efficacy. In the further challenging scenario of complex PCI, associated with a higher ischemic risk, the efficacy of an aspirin-free strategy, adopted shortly after the index event is under question, rendering decision-making a fairly difficult scenario for clinicians. Since patients with an indication for oral anticoagulation undergoing complex PCI are underrepresented in randomized trials, there are scarce data regarding the optimal treatment strategy in such patients. This review aims to analyze and compare different approaches regarding the type and duration of antithrombotic regimens, focusing on both safety and efficacy outcomes, as well as to discuss recent guidelines’ suggestions regarding the therapeutic approach in patients receiving oral anticoagulation undergoing PCI procedures of increased complexity.
format	article
author	Despoina-Rafailia Benetou Panayotis K Vlachakis Charalampos Varlamos Dimitrios Alexopoulos
author_facet	Despoina-Rafailia Benetou Panayotis K Vlachakis Charalampos Varlamos Dimitrios Alexopoulos
author_sort	Despoina-Rafailia Benetou
title	Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation
title_short	Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation
title_full	Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation
title_fullStr	Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation
title_full_unstemmed	Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation
title_sort	antithrombotic therapy in complex percutaneous coronary intervention patients requiring chronic anticoagulation
publisher	Radcliffe Medical Media
publishDate	2021
url	https://doaj.org/article/e373f115d45b402495e5748cca5ec0cc
work_keys_str_mv	AT despoinarafailiabenetou antithrombotictherapyincomplexpercutaneouscoronaryinterventionpatientsrequiringchronicanticoagulation AT panayotiskvlachakis antithrombotictherapyincomplexpercutaneouscoronaryinterventionpatientsrequiringchronicanticoagulation AT charalamposvarlamos antithrombotictherapyincomplexpercutaneouscoronaryinterventionpatientsrequiringchronicanticoagulation AT dimitriosalexopoulos antithrombotictherapyincomplexpercutaneouscoronaryinterventionpatientsrequiringchronicanticoagulation
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Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation

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