Concurrent X chromosome inactivation and upregulation during non-human primate preimplantation development revealed by single-cell RNA-sequencing

Abstract In mammals, dosage compensation of X-linked gene expression between males and females is achieved by inactivation of a single X chromosome in females, while upregulation of the single active X in males and females leads to X:autosome dosage balance. Studies in human embryos revealed that ra...

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Autores principales: Ana Luíza Cidral, Joana C. Moreira de Mello, Joost Gribnau, Lygia V. Pereira
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e378d0bcddb740f5be36ef0f11338c65
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