Adenovirus Early Proteins and Host Sumoylation

ABSTRACT The human adenovirus genome is transported into the nucleus, where viral gene transcription, viral DNA replication, and virion assembly take place. Posttranslational modifications by small ubiquitin-like modifiers (SUMOs) are implicated in the regulation of diverse cellular processes, parti...

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Autores principales:	Sook-Young Sohn, Patrick Hearing
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/e37a78c8acb14d24811c650272a4e06f
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spelling	oai:doaj.org-article:e37a78c8acb14d24811c650272a4e06f2021-11-15T15:50:16ZAdenovirus Early Proteins and Host Sumoylation10.1128/mBio.01154-162150-7511https://doaj.org/article/e37a78c8acb14d24811c650272a4e06f2016-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01154-16https://doaj.org/toc/2150-7511ABSTRACT The human adenovirus genome is transported into the nucleus, where viral gene transcription, viral DNA replication, and virion assembly take place. Posttranslational modifications by small ubiquitin-like modifiers (SUMOs) are implicated in the regulation of diverse cellular processes, particularly nuclear events. It is not surprising, therefore, that adenovirus modulates and utilizes the host sumoylation system. Adenovirus early proteins play an important role in establishing optimal host environments for virus replication within infected cells by stimulating the cell cycle and counteracting host antiviral defenses. Here, we review findings on the mechanisms and functional consequences of the interplay between human adenovirus early proteins and the host sumoylation system.Sook-Young SohnPatrick HearingAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 5 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Sook-Young Sohn Patrick Hearing Adenovirus Early Proteins and Host Sumoylation
description	ABSTRACT The human adenovirus genome is transported into the nucleus, where viral gene transcription, viral DNA replication, and virion assembly take place. Posttranslational modifications by small ubiquitin-like modifiers (SUMOs) are implicated in the regulation of diverse cellular processes, particularly nuclear events. It is not surprising, therefore, that adenovirus modulates and utilizes the host sumoylation system. Adenovirus early proteins play an important role in establishing optimal host environments for virus replication within infected cells by stimulating the cell cycle and counteracting host antiviral defenses. Here, we review findings on the mechanisms and functional consequences of the interplay between human adenovirus early proteins and the host sumoylation system.
format	article
author	Sook-Young Sohn Patrick Hearing
author_facet	Sook-Young Sohn Patrick Hearing
author_sort	Sook-Young Sohn
title	Adenovirus Early Proteins and Host Sumoylation
title_short	Adenovirus Early Proteins and Host Sumoylation
title_full	Adenovirus Early Proteins and Host Sumoylation
title_fullStr	Adenovirus Early Proteins and Host Sumoylation
title_full_unstemmed	Adenovirus Early Proteins and Host Sumoylation
title_sort	adenovirus early proteins and host sumoylation
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/e37a78c8acb14d24811c650272a4e06f
work_keys_str_mv	AT sookyoungsohn adenovirusearlyproteinsandhostsumoylation AT patrickhearing adenovirusearlyproteinsandhostsumoylation
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Adenovirus Early Proteins and Host Sumoylation

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