Convulsions in children hospitalized for acute gastroenteritis

Abstract The study aim was to examine possible correlates of convulsions in children hospitalized for acute gastroenteritis (AGE). Data collected in a prospective study of AGE hospitalizations in children aged 0–59 months in 3 hospitals in Israel during 2008–2015 were analyzed. Stool samples were te...

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Autores principales:	Moti Iflah, Eias Kassem, Uri Rubinstein, Sophy Goren, Moshe Ephros, Dani Cohen, Khitam Muhsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e37b993436684fcc8e660275f6c2de1c
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spelling	oai:doaj.org-article:e37b993436684fcc8e660275f6c2de1c2021-12-02T18:49:25ZConvulsions in children hospitalized for acute gastroenteritis10.1038/s41598-021-95202-42045-2322https://doaj.org/article/e37b993436684fcc8e660275f6c2de1c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95202-4https://doaj.org/toc/2045-2322Abstract The study aim was to examine possible correlates of convulsions in children hospitalized for acute gastroenteritis (AGE). Data collected in a prospective study of AGE hospitalizations in children aged 0–59 months in 3 hospitals in Israel during 2008–2015 were analyzed. Stool samples were tested for rotavirus using immunochromatography and stool culture was performed for the detection of Salmonella, Shigella and Campylobacter We compared clinical and demographic characteristics of children hospitalized for AGE who had convulsions (n = 68, cases) with children hospitalized for AGE without convulsions (n = 3505, controls). Age differed between children with and without convulsions (p = 0.005); the former were mostly toddlers aged 12–23 months (51%) compared to 30% of the control group. A higher percentage of cases tested positive for Shigella (11% vs. 4%, p = 0.002), the opposite was found for rotavirus (2% vs. 30% p < 0.001). A multivariable model showed that body temperature (OR 2.91 [95% CI 1.78–4.76], p < 0.001) and high blood glucose level (> 120 mg/dL) (OR 5.71 [95% CI 1.27–25.58] p = 0.023) were positively related to convulsions in children with AGE, while severe AGE (Vesikari score ≥ 11) was inversely related with convulsions (OR 0.09 [95% CI 0.03–0.24], p < 0.001). Conclusion: Elevated body temperature is associated with convulsions in children with AGE, but not severity of AGE, while hyperglycemia might reflect a neuroendocrine stress reaction to convulsions, AGE or both.Moti IflahEias KassemUri RubinsteinSophy GorenMoshe EphrosDani CohenKhitam MuhsenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Moti Iflah Eias Kassem Uri Rubinstein Sophy Goren Moshe Ephros Dani Cohen Khitam Muhsen Convulsions in children hospitalized for acute gastroenteritis
description	Abstract The study aim was to examine possible correlates of convulsions in children hospitalized for acute gastroenteritis (AGE). Data collected in a prospective study of AGE hospitalizations in children aged 0–59 months in 3 hospitals in Israel during 2008–2015 were analyzed. Stool samples were tested for rotavirus using immunochromatography and stool culture was performed for the detection of Salmonella, Shigella and Campylobacter We compared clinical and demographic characteristics of children hospitalized for AGE who had convulsions (n = 68, cases) with children hospitalized for AGE without convulsions (n = 3505, controls). Age differed between children with and without convulsions (p = 0.005); the former were mostly toddlers aged 12–23 months (51%) compared to 30% of the control group. A higher percentage of cases tested positive for Shigella (11% vs. 4%, p = 0.002), the opposite was found for rotavirus (2% vs. 30% p < 0.001). A multivariable model showed that body temperature (OR 2.91 [95% CI 1.78–4.76], p < 0.001) and high blood glucose level (> 120 mg/dL) (OR 5.71 [95% CI 1.27–25.58] p = 0.023) were positively related to convulsions in children with AGE, while severe AGE (Vesikari score ≥ 11) was inversely related with convulsions (OR 0.09 [95% CI 0.03–0.24], p < 0.001). Conclusion: Elevated body temperature is associated with convulsions in children with AGE, but not severity of AGE, while hyperglycemia might reflect a neuroendocrine stress reaction to convulsions, AGE or both.
format	article
author	Moti Iflah Eias Kassem Uri Rubinstein Sophy Goren Moshe Ephros Dani Cohen Khitam Muhsen
author_facet	Moti Iflah Eias Kassem Uri Rubinstein Sophy Goren Moshe Ephros Dani Cohen Khitam Muhsen
author_sort	Moti Iflah
title	Convulsions in children hospitalized for acute gastroenteritis
title_short	Convulsions in children hospitalized for acute gastroenteritis
title_full	Convulsions in children hospitalized for acute gastroenteritis
title_fullStr	Convulsions in children hospitalized for acute gastroenteritis
title_full_unstemmed	Convulsions in children hospitalized for acute gastroenteritis
title_sort	convulsions in children hospitalized for acute gastroenteritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e37b993436684fcc8e660275f6c2de1c
work_keys_str_mv	AT motiiflah convulsionsinchildrenhospitalizedforacutegastroenteritis AT eiaskassem convulsionsinchildrenhospitalizedforacutegastroenteritis AT urirubinstein convulsionsinchildrenhospitalizedforacutegastroenteritis AT sophygoren convulsionsinchildrenhospitalizedforacutegastroenteritis AT mosheephros convulsionsinchildrenhospitalizedforacutegastroenteritis AT danicohen convulsionsinchildrenhospitalizedforacutegastroenteritis AT khitammuhsen convulsionsinchildrenhospitalizedforacutegastroenteritis
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Convulsions in children hospitalized for acute gastroenteritis

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