A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2

Several mRNA-based vaccines for SARS-CoV-2 are in late phase clinical development. Here, the authors show that a single immunization with a mRNA vaccine expressing SARS-CoV-2 spike RBD induces neutralizing antibodies that are maintained for at least 6.5 months and confer protection in a sera transfe...

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Autores principales:	Qingrui Huang, Kai Ji, Siyu Tian, Fengze Wang, Baoying Huang, Zhou Tong, Shuguang Tan, Junfeng Hao, Qihui Wang, Wenjie Tan, George F. Gao, Jinghua Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e37e0ac7b8024061a8bb32d1d7084a2e
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spelling	oai:doaj.org-article:e37e0ac7b8024061a8bb32d1d7084a2e2021-12-02T14:06:10ZA single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-210.1038/s41467-021-21037-22041-1723https://doaj.org/article/e37e0ac7b8024061a8bb32d1d7084a2e2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21037-2https://doaj.org/toc/2041-1723Several mRNA-based vaccines for SARS-CoV-2 are in late phase clinical development. Here, the authors show that a single immunization with a mRNA vaccine expressing SARS-CoV-2 spike RBD induces neutralizing antibodies that are maintained for at least 6.5 months and confer protection in a sera transfer study in mice.Qingrui HuangKai JiSiyu TianFengze WangBaoying HuangZhou TongShuguang TanJunfeng HaoQihui WangWenjie TanGeorge F. GaoJinghua YanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qingrui Huang Kai Ji Siyu Tian Fengze Wang Baoying Huang Zhou Tong Shuguang Tan Junfeng Hao Qihui Wang Wenjie Tan George F. Gao Jinghua Yan A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2
description	Several mRNA-based vaccines for SARS-CoV-2 are in late phase clinical development. Here, the authors show that a single immunization with a mRNA vaccine expressing SARS-CoV-2 spike RBD induces neutralizing antibodies that are maintained for at least 6.5 months and confer protection in a sera transfer study in mice.
format	article
author	Qingrui Huang Kai Ji Siyu Tian Fengze Wang Baoying Huang Zhou Tong Shuguang Tan Junfeng Hao Qihui Wang Wenjie Tan George F. Gao Jinghua Yan
author_facet	Qingrui Huang Kai Ji Siyu Tian Fengze Wang Baoying Huang Zhou Tong Shuguang Tan Junfeng Hao Qihui Wang Wenjie Tan George F. Gao Jinghua Yan
author_sort	Qingrui Huang
title	A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2
title_short	A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2
title_full	A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2
title_fullStr	A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2
title_full_unstemmed	A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2
title_sort	single-dose mrna vaccine provides a long-term protection for hace2 transgenic mice from sars-cov-2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e37e0ac7b8024061a8bb32d1d7084a2e
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A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2

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