The bacterium endosymbiont of Crithidia deanei undergoes coordinated division with the host cell nucleus.

In trypanosomatids, cell division involves morphological changes and requires coordinated replication and segregation of the nucleus, kinetoplast and flagellum. In endosymbiont-containing trypanosomatids, like Crithidia deanei, this process is more complex, as each daughter cell contains only a sing...

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Autores principales:	Maria Cristina Machado Motta, Carolina Moura Costa Catta-Preta, Sergio Schenkman, Allan Cezar de Azevedo Martins, Kildare Miranda, Wanderley de Souza, Maria Carolina Elias
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e37e47eec7624b3daa198d37343d6a6b
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spelling	oai:doaj.org-article:e37e47eec7624b3daa198d37343d6a6b2021-11-18T06:35:40ZThe bacterium endosymbiont of Crithidia deanei undergoes coordinated division with the host cell nucleus.1932-620310.1371/journal.pone.0012415https://doaj.org/article/e37e47eec7624b3daa198d37343d6a6b2010-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20865129/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203In trypanosomatids, cell division involves morphological changes and requires coordinated replication and segregation of the nucleus, kinetoplast and flagellum. In endosymbiont-containing trypanosomatids, like Crithidia deanei, this process is more complex, as each daughter cell contains only a single symbiotic bacterium, indicating that the prokaryote must replicate synchronically with the host protozoan. In this study, we used light and electron microscopy combined with three-dimensional reconstruction approaches to observe the endosymbiont shape and division during C. deanei cell cycle. We found that the bacterium replicates before the basal body and kinetoplast segregations and that the nucleus is the last organelle to divide, before cytokinesis. In addition, the endosymbiont is usually found close to the host cell nucleus, presenting different shapes during the protozoan cell cycle. Considering that the endosymbiosis in trypanosomatids is a mutualistic relationship, which resembles organelle acquisition during evolution, these findings establish an excellent model for the understanding of mechanisms related with the establishment of organelles in eukaryotic cells.Maria Cristina Machado MottaCarolina Moura Costa Catta-PretaSergio SchenkmanAllan Cezar de Azevedo MartinsKildare MirandaWanderley de SouzaMaria Carolina EliasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 8, p e12415 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Cristina Machado Motta Carolina Moura Costa Catta-Preta Sergio Schenkman Allan Cezar de Azevedo Martins Kildare Miranda Wanderley de Souza Maria Carolina Elias The bacterium endosymbiont of Crithidia deanei undergoes coordinated division with the host cell nucleus.
description	In trypanosomatids, cell division involves morphological changes and requires coordinated replication and segregation of the nucleus, kinetoplast and flagellum. In endosymbiont-containing trypanosomatids, like Crithidia deanei, this process is more complex, as each daughter cell contains only a single symbiotic bacterium, indicating that the prokaryote must replicate synchronically with the host protozoan. In this study, we used light and electron microscopy combined with three-dimensional reconstruction approaches to observe the endosymbiont shape and division during C. deanei cell cycle. We found that the bacterium replicates before the basal body and kinetoplast segregations and that the nucleus is the last organelle to divide, before cytokinesis. In addition, the endosymbiont is usually found close to the host cell nucleus, presenting different shapes during the protozoan cell cycle. Considering that the endosymbiosis in trypanosomatids is a mutualistic relationship, which resembles organelle acquisition during evolution, these findings establish an excellent model for the understanding of mechanisms related with the establishment of organelles in eukaryotic cells.
format	article
author	Maria Cristina Machado Motta Carolina Moura Costa Catta-Preta Sergio Schenkman Allan Cezar de Azevedo Martins Kildare Miranda Wanderley de Souza Maria Carolina Elias
author_facet	Maria Cristina Machado Motta Carolina Moura Costa Catta-Preta Sergio Schenkman Allan Cezar de Azevedo Martins Kildare Miranda Wanderley de Souza Maria Carolina Elias
author_sort	Maria Cristina Machado Motta
title	The bacterium endosymbiont of Crithidia deanei undergoes coordinated division with the host cell nucleus.
title_short	The bacterium endosymbiont of Crithidia deanei undergoes coordinated division with the host cell nucleus.
title_full	The bacterium endosymbiont of Crithidia deanei undergoes coordinated division with the host cell nucleus.
title_fullStr	The bacterium endosymbiont of Crithidia deanei undergoes coordinated division with the host cell nucleus.
title_full_unstemmed	The bacterium endosymbiont of Crithidia deanei undergoes coordinated division with the host cell nucleus.
title_sort	bacterium endosymbiont of crithidia deanei undergoes coordinated division with the host cell nucleus.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/e37e47eec7624b3daa198d37343d6a6b
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The bacterium endosymbiont of Crithidia deanei undergoes coordinated division with the host cell nucleus.

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