SMYD2 glutathionylation contributes to degradation of sarcomeric proteins

Ischemic reperfusion or nutrient deprivation that produces reactive oxygen species can lead to a loss of muscle contractile function. Here the authors show that glutathionylation of the lysine methyltransferase SMYD2 contributes to degradation or disassembly of sarcomeres.

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Autores principales:	Dhanushka N. P. Munkanatta Godage, Garrett C. VanHecke, Kusal T. G. Samarasinghe, Han-Zhong Feng, Mark Hiske, Joshua Holcomb, Zhe Yang, Jian-Ping Jin, Charles S. Chung, Young-Hoon Ahn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e380dd272fcc4d37b01928dfbce9321f
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spelling	oai:doaj.org-article:e380dd272fcc4d37b01928dfbce9321f2021-12-02T17:32:31ZSMYD2 glutathionylation contributes to degradation of sarcomeric proteins10.1038/s41467-018-06786-x2041-1723https://doaj.org/article/e380dd272fcc4d37b01928dfbce9321f2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06786-xhttps://doaj.org/toc/2041-1723Ischemic reperfusion or nutrient deprivation that produces reactive oxygen species can lead to a loss of muscle contractile function. Here the authors show that glutathionylation of the lysine methyltransferase SMYD2 contributes to degradation or disassembly of sarcomeres.Dhanushka N. P. Munkanatta GodageGarrett C. VanHeckeKusal T. G. SamarasingheHan-Zhong FengMark HiskeJoshua HolcombZhe YangJian-Ping JinCharles S. ChungYoung-Hoon AhnNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dhanushka N. P. Munkanatta Godage Garrett C. VanHecke Kusal T. G. Samarasinghe Han-Zhong Feng Mark Hiske Joshua Holcomb Zhe Yang Jian-Ping Jin Charles S. Chung Young-Hoon Ahn SMYD2 glutathionylation contributes to degradation of sarcomeric proteins
description	Ischemic reperfusion or nutrient deprivation that produces reactive oxygen species can lead to a loss of muscle contractile function. Here the authors show that glutathionylation of the lysine methyltransferase SMYD2 contributes to degradation or disassembly of sarcomeres.
format	article
author	Dhanushka N. P. Munkanatta Godage Garrett C. VanHecke Kusal T. G. Samarasinghe Han-Zhong Feng Mark Hiske Joshua Holcomb Zhe Yang Jian-Ping Jin Charles S. Chung Young-Hoon Ahn
author_facet	Dhanushka N. P. Munkanatta Godage Garrett C. VanHecke Kusal T. G. Samarasinghe Han-Zhong Feng Mark Hiske Joshua Holcomb Zhe Yang Jian-Ping Jin Charles S. Chung Young-Hoon Ahn
author_sort	Dhanushka N. P. Munkanatta Godage
title	SMYD2 glutathionylation contributes to degradation of sarcomeric proteins
title_short	SMYD2 glutathionylation contributes to degradation of sarcomeric proteins
title_full	SMYD2 glutathionylation contributes to degradation of sarcomeric proteins
title_fullStr	SMYD2 glutathionylation contributes to degradation of sarcomeric proteins
title_full_unstemmed	SMYD2 glutathionylation contributes to degradation of sarcomeric proteins
title_sort	smyd2 glutathionylation contributes to degradation of sarcomeric proteins
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e380dd272fcc4d37b01928dfbce9321f
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SMYD2 glutathionylation contributes to degradation of sarcomeric proteins

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