SMYD2 glutathionylation contributes to degradation of sarcomeric proteins

Ischemic reperfusion or nutrient deprivation that produces reactive oxygen species can lead to a loss of muscle contractile function. Here the authors show that glutathionylation of the lysine methyltransferase SMYD2 contributes to degradation or disassembly of sarcomeres.

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Autores principales: Dhanushka N. P. Munkanatta Godage, Garrett C. VanHecke, Kusal T. G. Samarasinghe, Han-Zhong Feng, Mark Hiske, Joshua Holcomb, Zhe Yang, Jian-Ping Jin, Charles S. Chung, Young-Hoon Ahn
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/e380dd272fcc4d37b01928dfbce9321f
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