Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH

Many bacterial pathogens use a type III secretion system (T3SS) to inject effector proteins into host cells. Here, Wimmi et al. show that the external pH regulates the assembly of T3SS cytosolic components in intestinal pathogens, thus preventing T3SS activity in the stomach and allowing T3SS reacti...

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Autores principales:	Stephan Wimmi, Alexander Balinovic, Hannah Jeckel, Lisa Selinger, Dimitrios Lampaki, Emma Eisemann, Ina Meuskens, Dirk Linke, Knut Drescher, Ulrike Endesfelder, Andreas Diepold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e383a928c6b94e53a167b0dafed63b15
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spelling	oai:doaj.org-article:e383a928c6b94e53a167b0dafed63b152021-12-02T11:36:21ZDynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH10.1038/s41467-021-21863-42041-1723https://doaj.org/article/e383a928c6b94e53a167b0dafed63b152021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21863-4https://doaj.org/toc/2041-1723Many bacterial pathogens use a type III secretion system (T3SS) to inject effector proteins into host cells. Here, Wimmi et al. show that the external pH regulates the assembly of T3SS cytosolic components in intestinal pathogens, thus preventing T3SS activity in the stomach and allowing T3SS reactivation in the intestine.Stephan WimmiAlexander BalinovicHannah JeckelLisa SelingerDimitrios LampakiEmma EisemannIna MeuskensDirk LinkeKnut DrescherUlrike EndesfelderAndreas DiepoldNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephan Wimmi Alexander Balinovic Hannah Jeckel Lisa Selinger Dimitrios Lampaki Emma Eisemann Ina Meuskens Dirk Linke Knut Drescher Ulrike Endesfelder Andreas Diepold Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH
description	Many bacterial pathogens use a type III secretion system (T3SS) to inject effector proteins into host cells. Here, Wimmi et al. show that the external pH regulates the assembly of T3SS cytosolic components in intestinal pathogens, thus preventing T3SS activity in the stomach and allowing T3SS reactivation in the intestine.
format	article
author	Stephan Wimmi Alexander Balinovic Hannah Jeckel Lisa Selinger Dimitrios Lampaki Emma Eisemann Ina Meuskens Dirk Linke Knut Drescher Ulrike Endesfelder Andreas Diepold
author_facet	Stephan Wimmi Alexander Balinovic Hannah Jeckel Lisa Selinger Dimitrios Lampaki Emma Eisemann Ina Meuskens Dirk Linke Knut Drescher Ulrike Endesfelder Andreas Diepold
author_sort	Stephan Wimmi
title	Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH
title_short	Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH
title_full	Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH
title_fullStr	Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH
title_full_unstemmed	Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH
title_sort	dynamic relocalization of cytosolic type iii secretion system components prevents premature protein secretion at low external ph
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e383a928c6b94e53a167b0dafed63b15
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Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH

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