Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses

SK Mohiuddin Choudhury,* XuSheng Ma,* Sahibzada Waheed Abdullah, HaiXue Zheng State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Aca...

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Autores principales:	Choudhury SM, Ma X, Abdullah SW, Zheng H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	inflammation nlrp3 inflammasome rna viruses activation and inhibition of nlrp3 viral protein and genome Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e3848749fc234bef9799245b658e85e1
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spelling	oai:doaj.org-article:e3848749fc234bef9799245b658e85e12021-12-02T13:24:28ZActivation and Inhibition of the NLRP3 Inflammasome by RNA Viruses1178-7031https://doaj.org/article/e3848749fc234bef9799245b658e85e12021-03-01T00:00:00Zhttps://www.dovepress.com/activation-and-inhibition-of-the-nlrp3-inflammasome-by-rna-viruses-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031SK Mohiuddin Choudhury,* XuSheng Ma,* Sahibzada Waheed Abdullah, HaiXue Zheng State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, People’s Republic of China*These authors contributed equally to this workCorrespondence: HaiXue ZhengState Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, People’s Republic of ChinaTel +86-931-8342086Email haixuezheng@163.comAbstract: Inflammation refers to the response of the immune system to viral, bacterial, and fungal infections, or other foreign particles in the body, which can involve the production of a wide array of soluble inflammatory mediators. It is important for the development of many RNA virus-infected diseases. The primary factors through which the infection becomes inflammation involve inflammasome. Inflammasomes are proteins complex that the activation is responsive to specific pathogens, host cell damage, and other environmental stimuli. Inflammasomes bring about the maturation of various pro-inflammatory cytokines such as IL-18 and IL-1β in order to mediate the innate immune defense mechanisms. Many RNA viruses and their components, such as encephalomyocarditis virus (EMCV) 2B viroporin, the viral RNA of hepatitis C virus, the influenza virus M2 viroporin, the respiratory syncytial virus (RSV) small hydrophobic (SH) viroporin, and the human rhinovirus (HRV) 2B viroporin can activate the Nod-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome to influence the inflammatory response. On the other hand, several viruses use virus-encoded proteins to suppress inflammation activation, such as the influenza virus NS1 protein and the measles virus (MV) V protein. In this review, we summarize how RNA virus infection leads to the activation or inhibition of the NLRP3 inflammasome.Keywords: inflammation, NLRP3 inflammasome, RNA viruses, activation and inhibition of NLRP3, viral protein and genomeChoudhury SMMa XAbdullah SWZheng HDove Medical Pressarticleinflammationnlrp3 inflammasomerna virusesactivation and inhibition of nlrp3viral protein and genomePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 1145-1163 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammation nlrp3 inflammasome rna viruses activation and inhibition of nlrp3 viral protein and genome Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	inflammation nlrp3 inflammasome rna viruses activation and inhibition of nlrp3 viral protein and genome Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Choudhury SM Ma X Abdullah SW Zheng H Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses
description	SK Mohiuddin Choudhury,* XuSheng Ma,* Sahibzada Waheed Abdullah, HaiXue Zheng State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, People’s Republic of China*These authors contributed equally to this workCorrespondence: HaiXue ZhengState Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, People’s Republic of ChinaTel +86-931-8342086Email haixuezheng@163.comAbstract: Inflammation refers to the response of the immune system to viral, bacterial, and fungal infections, or other foreign particles in the body, which can involve the production of a wide array of soluble inflammatory mediators. It is important for the development of many RNA virus-infected diseases. The primary factors through which the infection becomes inflammation involve inflammasome. Inflammasomes are proteins complex that the activation is responsive to specific pathogens, host cell damage, and other environmental stimuli. Inflammasomes bring about the maturation of various pro-inflammatory cytokines such as IL-18 and IL-1β in order to mediate the innate immune defense mechanisms. Many RNA viruses and their components, such as encephalomyocarditis virus (EMCV) 2B viroporin, the viral RNA of hepatitis C virus, the influenza virus M2 viroporin, the respiratory syncytial virus (RSV) small hydrophobic (SH) viroporin, and the human rhinovirus (HRV) 2B viroporin can activate the Nod-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome to influence the inflammatory response. On the other hand, several viruses use virus-encoded proteins to suppress inflammation activation, such as the influenza virus NS1 protein and the measles virus (MV) V protein. In this review, we summarize how RNA virus infection leads to the activation or inhibition of the NLRP3 inflammasome.Keywords: inflammation, NLRP3 inflammasome, RNA viruses, activation and inhibition of NLRP3, viral protein and genome
format	article
author	Choudhury SM Ma X Abdullah SW Zheng H
author_facet	Choudhury SM Ma X Abdullah SW Zheng H
author_sort	Choudhury SM
title	Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses
title_short	Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses
title_full	Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses
title_fullStr	Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses
title_full_unstemmed	Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses
title_sort	activation and inhibition of the nlrp3 inflammasome by rna viruses
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e3848749fc234bef9799245b658e85e1
work_keys_str_mv	AT choudhurysm activationandinhibitionofthenlrp3inflammasomebyrnaviruses AT max activationandinhibitionofthenlrp3inflammasomebyrnaviruses AT abdullahsw activationandinhibitionofthenlrp3inflammasomebyrnaviruses AT zhengh activationandinhibitionofthenlrp3inflammasomebyrnaviruses
_version_	1718393125135712256

Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses

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