Fish oil supplementation to rats fed high-fat diet during pregnancy prevents development of impaired insulin sensitivity in male adult offspring

Abstract We examined whether maternal fish oil supplementation during pregnancy could prevent development of insulin resistance in adult male offspring of rat dams fed a high-fat diet. Time-mated Sprague-Dawley rat dams were randomised into four treatment groups: Con-Con, dams fed a control diet (fa...

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Autores principales:	Benjamin B. Albert, Mark H. Vickers, Clint Gray, Clare M. Reynolds, Stephanie A. Segovia, José G. B. Derraik, Manohar L. Garg, David Cameron-Smith, Paul L. Hofman, Wayne S. Cutfield
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e385905550f64c3091fd35ab812d39d9
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spelling	oai:doaj.org-article:e385905550f64c3091fd35ab812d39d92021-12-02T12:32:55ZFish oil supplementation to rats fed high-fat diet during pregnancy prevents development of impaired insulin sensitivity in male adult offspring10.1038/s41598-017-05793-02045-2322https://doaj.org/article/e385905550f64c3091fd35ab812d39d92017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05793-0https://doaj.org/toc/2045-2322Abstract We examined whether maternal fish oil supplementation during pregnancy could prevent development of insulin resistance in adult male offspring of rat dams fed a high-fat diet. Time-mated Sprague-Dawley rat dams were randomised into four treatment groups: Con-Con, dams fed a control diet (fat: 15% kcal) and administered water by gavage; Con-FO, control diet with unoxidised fish oil by gavage; HF-Con, high-fat diet (fat: 45% kcal) and water by gavage; and HF-FO, high-fat diet and unoxidised fish oil by gavage. Dams were fed the allocated diet ad libitum during pregnancy and lactation, but daily gavage occurred only during pregnancy. After weaning, male offspring consumed a chow diet ad libitum until adulthood. Maternal high-fat diet led to increased food consumption, adiposity, systolic blood pressure, and triglycerides and plasma leptin in adult HF-Con offspring. HF-Con offspring also exhibited lower insulin sensitivity than Con-Con rats. Male offspring from HF-FO group were similar to HF-Con regarding food consumption and most metabolic parameters. However, insulin sensitivity in the HF-FO group was improved relative to the HF-Con offspring. Supplementation with unoxidised n-3 PUFA rich oils in the setting of a maternal obesogenic diet improved insulin sensitivity, but had no impact on body composition of adult male offspring.Benjamin B. AlbertMark H. VickersClint GrayClare M. ReynoldsStephanie A. SegoviaJosé G. B. DerraikManohar L. GargDavid Cameron-SmithPaul L. HofmanWayne S. CutfieldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Benjamin B. Albert Mark H. Vickers Clint Gray Clare M. Reynolds Stephanie A. Segovia José G. B. Derraik Manohar L. Garg David Cameron-Smith Paul L. Hofman Wayne S. Cutfield Fish oil supplementation to rats fed high-fat diet during pregnancy prevents development of impaired insulin sensitivity in male adult offspring
description	Abstract We examined whether maternal fish oil supplementation during pregnancy could prevent development of insulin resistance in adult male offspring of rat dams fed a high-fat diet. Time-mated Sprague-Dawley rat dams were randomised into four treatment groups: Con-Con, dams fed a control diet (fat: 15% kcal) and administered water by gavage; Con-FO, control diet with unoxidised fish oil by gavage; HF-Con, high-fat diet (fat: 45% kcal) and water by gavage; and HF-FO, high-fat diet and unoxidised fish oil by gavage. Dams were fed the allocated diet ad libitum during pregnancy and lactation, but daily gavage occurred only during pregnancy. After weaning, male offspring consumed a chow diet ad libitum until adulthood. Maternal high-fat diet led to increased food consumption, adiposity, systolic blood pressure, and triglycerides and plasma leptin in adult HF-Con offspring. HF-Con offspring also exhibited lower insulin sensitivity than Con-Con rats. Male offspring from HF-FO group were similar to HF-Con regarding food consumption and most metabolic parameters. However, insulin sensitivity in the HF-FO group was improved relative to the HF-Con offspring. Supplementation with unoxidised n-3 PUFA rich oils in the setting of a maternal obesogenic diet improved insulin sensitivity, but had no impact on body composition of adult male offspring.
format	article
author	Benjamin B. Albert Mark H. Vickers Clint Gray Clare M. Reynolds Stephanie A. Segovia José G. B. Derraik Manohar L. Garg David Cameron-Smith Paul L. Hofman Wayne S. Cutfield
author_facet	Benjamin B. Albert Mark H. Vickers Clint Gray Clare M. Reynolds Stephanie A. Segovia José G. B. Derraik Manohar L. Garg David Cameron-Smith Paul L. Hofman Wayne S. Cutfield
author_sort	Benjamin B. Albert
title	Fish oil supplementation to rats fed high-fat diet during pregnancy prevents development of impaired insulin sensitivity in male adult offspring
title_short	Fish oil supplementation to rats fed high-fat diet during pregnancy prevents development of impaired insulin sensitivity in male adult offspring
title_full	Fish oil supplementation to rats fed high-fat diet during pregnancy prevents development of impaired insulin sensitivity in male adult offspring
title_fullStr	Fish oil supplementation to rats fed high-fat diet during pregnancy prevents development of impaired insulin sensitivity in male adult offspring
title_full_unstemmed	Fish oil supplementation to rats fed high-fat diet during pregnancy prevents development of impaired insulin sensitivity in male adult offspring
title_sort	fish oil supplementation to rats fed high-fat diet during pregnancy prevents development of impaired insulin sensitivity in male adult offspring
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e385905550f64c3091fd35ab812d39d9
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Fish oil supplementation to rats fed high-fat diet during pregnancy prevents development of impaired insulin sensitivity in male adult offspring

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