Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children

Somatic hypermutation of antibodies can occur in infants but are difficult to track. Here the authors present a new method called MIDCIRS for deep quantitative repertoire sequencing with few cells, and show infants as young as 3 months can expand antibody lineage complexity in response to malaria in...

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Autores principales:	Ben S. Wendel, Chenfeng He, Mingjuan Qu, Di Wu, Stefany M. Hernandez, Ke-Yue Ma, Eugene W. Liu, Jun Xiao, Peter D. Crompton, Susan K. Pierce, Pengyu Ren, Keke Chen, Ning Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e3859fc7336a44ffae74cb5a14acbd04
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spelling	oai:doaj.org-article:e3859fc7336a44ffae74cb5a14acbd042021-12-02T17:06:13ZAccurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children10.1038/s41467-017-00645-x2041-1723https://doaj.org/article/e3859fc7336a44ffae74cb5a14acbd042017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00645-xhttps://doaj.org/toc/2041-1723Somatic hypermutation of antibodies can occur in infants but are difficult to track. Here the authors present a new method called MIDCIRS for deep quantitative repertoire sequencing with few cells, and show infants as young as 3 months can expand antibody lineage complexity in response to malaria infection.Ben S. WendelChenfeng HeMingjuan QuDi WuStefany M. HernandezKe-Yue MaEugene W. LiuJun XiaoPeter D. CromptonSusan K. PiercePengyu RenKeke ChenNing JiangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ben S. Wendel Chenfeng He Mingjuan Qu Di Wu Stefany M. Hernandez Ke-Yue Ma Eugene W. Liu Jun Xiao Peter D. Crompton Susan K. Pierce Pengyu Ren Keke Chen Ning Jiang Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children
description	Somatic hypermutation of antibodies can occur in infants but are difficult to track. Here the authors present a new method called MIDCIRS for deep quantitative repertoire sequencing with few cells, and show infants as young as 3 months can expand antibody lineage complexity in response to malaria infection.
format	article
author	Ben S. Wendel Chenfeng He Mingjuan Qu Di Wu Stefany M. Hernandez Ke-Yue Ma Eugene W. Liu Jun Xiao Peter D. Crompton Susan K. Pierce Pengyu Ren Keke Chen Ning Jiang
author_facet	Ben S. Wendel Chenfeng He Mingjuan Qu Di Wu Stefany M. Hernandez Ke-Yue Ma Eugene W. Liu Jun Xiao Peter D. Crompton Susan K. Pierce Pengyu Ren Keke Chen Ning Jiang
author_sort	Ben S. Wendel
title	Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children
title_short	Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children
title_full	Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children
title_fullStr	Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children
title_full_unstemmed	Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children
title_sort	accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e3859fc7336a44ffae74cb5a14acbd04
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Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children

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