CYTOKINE PROFILE FEATURES IN THE PATIENTS WITH NONALLERGIC BRONCHIAL ASTHMA WITH CO-EXISTING TYPE 2 DIABETES MELLITUS

Thirty-five patients with non-allergic bronchial asthma (NABA), 22 patients with NABA and diabetes mellitus type 2 (DT2), 23 subjects with DT2, and 31 healthy controls were enrolled into the study. ELISA assays for IL-4, IL-10, IL-6, IFNγ were performed by means of a standardized protocol using immu...

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Autores principales:	L. N. Sorokina, V. A. Ivanov, V. V. Lim, V. N. Mineev, V. I. Trofimov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	bronchial asthma diabetes type 2 cytokines il-4 il-10 il-6 ifnγ tnfα Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e3879873539340328c118bbbd8f57c6c
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spelling	oai:doaj.org-article:e3879873539340328c118bbbd8f57c6c2021-11-18T08:03:46ZCYTOKINE PROFILE FEATURES IN THE PATIENTS WITH NONALLERGIC BRONCHIAL ASTHMA WITH CO-EXISTING TYPE 2 DIABETES MELLITUS1563-06252313-741X10.15789/1563-0625-2017-3-313-318https://doaj.org/article/e3879873539340328c118bbbd8f57c6c2017-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1266https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThirty-five patients with non-allergic bronchial asthma (NABA), 22 patients with NABA and diabetes mellitus type 2 (DT2), 23 subjects with DT2, and 31 healthy controls were enrolled into the study. ELISA assays for IL-4, IL-10, IL-6, IFNγ were performed by means of a standardized protocol using immunoassay kits purchased from VectorBest, and Cytokine. In asthma patients complicated by DT2, the pattern of bronchial asthma was ascribed to NABA. This finding may be consistent with a theory of specific insulin-receptor interactions in asthma. The NABA patients with type 2 diabetes mellitus exhibited a significant increase in IL-6, IFNγ, and decrease of IL-4, as compared with healthy controls and NABA. Moreover, we have revealed an increase of IL-4, IL-6, IFNγ, when compared with DT2. Hence, the patients with coexistence of non-allergic bronchial asthma and DT2 were characterized by a specific cytokine profile of pro- and anti-inflammatory cytokines, which may correlate with increased glycation and deterioration of lung function.L. N. SorokinaV. A. IvanovV. V. LimV. N. MineevV. I. TrofimovSPb RAACIarticlebronchial asthmadiabetes type 2cytokinesil-4il-10il-6ifnγtnfαImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 3, Pp 313-318 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	bronchial asthma diabetes type 2 cytokines il-4 il-10 il-6 ifnγ tnfα Immunologic diseases. Allergy RC581-607
spellingShingle	bronchial asthma diabetes type 2 cytokines il-4 il-10 il-6 ifnγ tnfα Immunologic diseases. Allergy RC581-607 L. N. Sorokina V. A. Ivanov V. V. Lim V. N. Mineev V. I. Trofimov CYTOKINE PROFILE FEATURES IN THE PATIENTS WITH NONALLERGIC BRONCHIAL ASTHMA WITH CO-EXISTING TYPE 2 DIABETES MELLITUS
description	Thirty-five patients with non-allergic bronchial asthma (NABA), 22 patients with NABA and diabetes mellitus type 2 (DT2), 23 subjects with DT2, and 31 healthy controls were enrolled into the study. ELISA assays for IL-4, IL-10, IL-6, IFNγ were performed by means of a standardized protocol using immunoassay kits purchased from VectorBest, and Cytokine. In asthma patients complicated by DT2, the pattern of bronchial asthma was ascribed to NABA. This finding may be consistent with a theory of specific insulin-receptor interactions in asthma. The NABA patients with type 2 diabetes mellitus exhibited a significant increase in IL-6, IFNγ, and decrease of IL-4, as compared with healthy controls and NABA. Moreover, we have revealed an increase of IL-4, IL-6, IFNγ, when compared with DT2. Hence, the patients with coexistence of non-allergic bronchial asthma and DT2 were characterized by a specific cytokine profile of pro- and anti-inflammatory cytokines, which may correlate with increased glycation and deterioration of lung function.
format	article
author	L. N. Sorokina V. A. Ivanov V. V. Lim V. N. Mineev V. I. Trofimov
author_facet	L. N. Sorokina V. A. Ivanov V. V. Lim V. N. Mineev V. I. Trofimov
author_sort	L. N. Sorokina
title	CYTOKINE PROFILE FEATURES IN THE PATIENTS WITH NONALLERGIC BRONCHIAL ASTHMA WITH CO-EXISTING TYPE 2 DIABETES MELLITUS
title_short	CYTOKINE PROFILE FEATURES IN THE PATIENTS WITH NONALLERGIC BRONCHIAL ASTHMA WITH CO-EXISTING TYPE 2 DIABETES MELLITUS
title_full	CYTOKINE PROFILE FEATURES IN THE PATIENTS WITH NONALLERGIC BRONCHIAL ASTHMA WITH CO-EXISTING TYPE 2 DIABETES MELLITUS
title_fullStr	CYTOKINE PROFILE FEATURES IN THE PATIENTS WITH NONALLERGIC BRONCHIAL ASTHMA WITH CO-EXISTING TYPE 2 DIABETES MELLITUS
title_full_unstemmed	CYTOKINE PROFILE FEATURES IN THE PATIENTS WITH NONALLERGIC BRONCHIAL ASTHMA WITH CO-EXISTING TYPE 2 DIABETES MELLITUS
title_sort	cytokine profile features in the patients with nonallergic bronchial asthma with co-existing type 2 diabetes mellitus
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/e3879873539340328c118bbbd8f57c6c
work_keys_str_mv	AT lnsorokina cytokineprofilefeaturesinthepatientswithnonallergicbronchialasthmawithcoexistingtype2diabetesmellitus AT vaivanov cytokineprofilefeaturesinthepatientswithnonallergicbronchialasthmawithcoexistingtype2diabetesmellitus AT vvlim cytokineprofilefeaturesinthepatientswithnonallergicbronchialasthmawithcoexistingtype2diabetesmellitus AT vnmineev cytokineprofilefeaturesinthepatientswithnonallergicbronchialasthmawithcoexistingtype2diabetesmellitus AT vitrofimov cytokineprofilefeaturesinthepatientswithnonallergicbronchialasthmawithcoexistingtype2diabetesmellitus
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CYTOKINE PROFILE FEATURES IN THE PATIENTS WITH NONALLERGIC BRONCHIAL ASTHMA WITH CO-EXISTING TYPE 2 DIABETES MELLITUS

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