DciA is an ancestral replicative helicase operator essential for bacterial replication initiation

DNA replication requires the loading of the replicative helicase onto the DNA molecule; in bacteria this was believed to be solely accomplished by DnaC and DnaI. Here the authors identify DciA as an ancestral and still widely distributed replicative helicase loader.

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Detalles Bibliográficos
Autores principales: Pierre Brézellec, Isabelle Vallet-Gely, Christophe Possoz, Sophie Quevillon-Cheruel, Jean-Luc Ferat
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/e3892538e96845709c4a3f9500a75803
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Sumario:DNA replication requires the loading of the replicative helicase onto the DNA molecule; in bacteria this was believed to be solely accomplished by DnaC and DnaI. Here the authors identify DciA as an ancestral and still widely distributed replicative helicase loader.