Improvement in the long-term care burden after surgical treatment of patients with idiopathic normal pressure hydrocephalus: a supplementary study

Abstract Idiopathic normal pressure hydrocephalus (iNPH) is a surgically treatable syndrome commonly observed in older adults. However, it is unclear whether clinical improvements after surgery can effectively reduce the long-term care burden (LTCB). In this study, we determined whether shunt surger...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Masatsune Ishikawa, Shigeki Yamada, Masakazu Miyajima, Hiroaki Kazui, Etsuro Mori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e39301908fa149b2a74adc9025515d65
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e39301908fa149b2a74adc9025515d65
record_format	dspace
spelling	oai:doaj.org-article:e39301908fa149b2a74adc9025515d652021-12-02T17:51:21ZImprovement in the long-term care burden after surgical treatment of patients with idiopathic normal pressure hydrocephalus: a supplementary study10.1038/s41598-021-90911-22045-2322https://doaj.org/article/e39301908fa149b2a74adc9025515d652021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90911-2https://doaj.org/toc/2045-2322Abstract Idiopathic normal pressure hydrocephalus (iNPH) is a surgically treatable syndrome commonly observed in older adults. However, it is unclear whether clinical improvements after surgery can effectively reduce the long-term care burden (LTCB). In this study, we determined whether shunt surgery was effective in decreasing LTCB. We also investigated the degree of variability in patients and hospitals, using data from the iNPH multicenter study. This study involved 69 participants who underwent lumboperitoneal shunt surgery with follow-up for 12 months. A generalized linear mixed model was applied to analyze the fixed and random effects simultaneously. Regarding LTCB, the disability grades improved significantly. Although the dementia grades also improved, it was not statistically significant. The differences in the LTCB grades in most patients were within the range of the 95% confidence intervals, while in the case of hospitals, some were often out of the range. Further studies are needed to improve dementia in patients with iNPH. The incorporation of random variables, such as hospitals, is important for the analysis of data from multicenter studies.Masatsune IshikawaShigeki YamadaMasakazu MiyajimaHiroaki KazuiEtsuro MoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masatsune Ishikawa Shigeki Yamada Masakazu Miyajima Hiroaki Kazui Etsuro Mori Improvement in the long-term care burden after surgical treatment of patients with idiopathic normal pressure hydrocephalus: a supplementary study
description	Abstract Idiopathic normal pressure hydrocephalus (iNPH) is a surgically treatable syndrome commonly observed in older adults. However, it is unclear whether clinical improvements after surgery can effectively reduce the long-term care burden (LTCB). In this study, we determined whether shunt surgery was effective in decreasing LTCB. We also investigated the degree of variability in patients and hospitals, using data from the iNPH multicenter study. This study involved 69 participants who underwent lumboperitoneal shunt surgery with follow-up for 12 months. A generalized linear mixed model was applied to analyze the fixed and random effects simultaneously. Regarding LTCB, the disability grades improved significantly. Although the dementia grades also improved, it was not statistically significant. The differences in the LTCB grades in most patients were within the range of the 95% confidence intervals, while in the case of hospitals, some were often out of the range. Further studies are needed to improve dementia in patients with iNPH. The incorporation of random variables, such as hospitals, is important for the analysis of data from multicenter studies.
format	article
author	Masatsune Ishikawa Shigeki Yamada Masakazu Miyajima Hiroaki Kazui Etsuro Mori
author_facet	Masatsune Ishikawa Shigeki Yamada Masakazu Miyajima Hiroaki Kazui Etsuro Mori
author_sort	Masatsune Ishikawa
title	Improvement in the long-term care burden after surgical treatment of patients with idiopathic normal pressure hydrocephalus: a supplementary study
title_short	Improvement in the long-term care burden after surgical treatment of patients with idiopathic normal pressure hydrocephalus: a supplementary study
title_full	Improvement in the long-term care burden after surgical treatment of patients with idiopathic normal pressure hydrocephalus: a supplementary study
title_fullStr	Improvement in the long-term care burden after surgical treatment of patients with idiopathic normal pressure hydrocephalus: a supplementary study
title_full_unstemmed	Improvement in the long-term care burden after surgical treatment of patients with idiopathic normal pressure hydrocephalus: a supplementary study
title_sort	improvement in the long-term care burden after surgical treatment of patients with idiopathic normal pressure hydrocephalus: a supplementary study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e39301908fa149b2a74adc9025515d65
work_keys_str_mv	AT masatsuneishikawa improvementinthelongtermcareburdenaftersurgicaltreatmentofpatientswithidiopathicnormalpressurehydrocephalusasupplementarystudy AT shigekiyamada improvementinthelongtermcareburdenaftersurgicaltreatmentofpatientswithidiopathicnormalpressurehydrocephalusasupplementarystudy AT masakazumiyajima improvementinthelongtermcareburdenaftersurgicaltreatmentofpatientswithidiopathicnormalpressurehydrocephalusasupplementarystudy AT hiroakikazui improvementinthelongtermcareburdenaftersurgicaltreatmentofpatientswithidiopathicnormalpressurehydrocephalusasupplementarystudy AT etsuromori improvementinthelongtermcareburdenaftersurgicaltreatmentofpatientswithidiopathicnormalpressurehydrocephalusasupplementarystudy
_version_	1718379258392346624

Improvement in the long-term care burden after surgical treatment of patients with idiopathic normal pressure hydrocephalus: a supplementary study

Ejemplares similares