ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer

Abstract The human AlkB homolog family (ALKBH) of proteins play a critical role in some types of cancer. However, the expression and function of the lysine demethylase ALKBH4 in cancer are poorly understood. Here, we examined the expression and function of ALKBH4 in non-small-cell lung cancer (NSCLC...

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Autores principales:	Kentaro Jingushi, Masaya Aoki, Kazuhiro Ueda, Takahiro Kogaki, Masaya Tanimoto, Yuya Monoe, Masayuki Ando, Takuya Matsumoto, Kentaro Minami, Yuko Ueda, Kaori Kitae, Hiroaki Hase, Toshiyuki Nagata, Aya Harada-Takeda, Masatatsu Yamamoto, Kohichi Kawahara, Kazuhiro Tabata, Tatsuhiko Furukawa, Masami Sato, Kazutake Tsujikawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e39422a1faab4dfe81c736644fc55860
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spelling	oai:doaj.org-article:e39422a1faab4dfe81c736644fc558602021-12-02T18:27:49ZALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer10.1038/s41598-021-87763-12045-2322https://doaj.org/article/e39422a1faab4dfe81c736644fc558602021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87763-1https://doaj.org/toc/2045-2322Abstract The human AlkB homolog family (ALKBH) of proteins play a critical role in some types of cancer. However, the expression and function of the lysine demethylase ALKBH4 in cancer are poorly understood. Here, we examined the expression and function of ALKBH4 in non-small-cell lung cancer (NSCLC) and found that ALKBH4 was highly expressed in NSCLC, as compared to that in adjacent normal lung tissues. ALKBH4 knockdown significantly induced the downregulation of NSCLC cell proliferation via cell cycle arrest at the G1 phase of in vivo tumour growth. ALKBH4 knockdown downregulated E2F transcription factor 1 (E2F1) and its target gene expression in NSCLC cells. ALKBH4 and E2F1 expression was significantly correlated in NSCLC clinical specimens. Moreover, patients with high ALKBH4 expression showed a poor prognosis, suggesting that ALKBH4 plays a pivotal tumour-promoting role in NSCLC.Kentaro JingushiMasaya AokiKazuhiro UedaTakahiro KogakiMasaya TanimotoYuya MonoeMasayuki AndoTakuya MatsumotoKentaro MinamiYuko UedaKaori KitaeHiroaki HaseToshiyuki NagataAya Harada-TakedaMasatatsu YamamotoKohichi KawaharaKazuhiro TabataTatsuhiko FurukawaMasami SatoKazutake TsujikawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kentaro Jingushi Masaya Aoki Kazuhiro Ueda Takahiro Kogaki Masaya Tanimoto Yuya Monoe Masayuki Ando Takuya Matsumoto Kentaro Minami Yuko Ueda Kaori Kitae Hiroaki Hase Toshiyuki Nagata Aya Harada-Takeda Masatatsu Yamamoto Kohichi Kawahara Kazuhiro Tabata Tatsuhiko Furukawa Masami Sato Kazutake Tsujikawa ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer
description	Abstract The human AlkB homolog family (ALKBH) of proteins play a critical role in some types of cancer. However, the expression and function of the lysine demethylase ALKBH4 in cancer are poorly understood. Here, we examined the expression and function of ALKBH4 in non-small-cell lung cancer (NSCLC) and found that ALKBH4 was highly expressed in NSCLC, as compared to that in adjacent normal lung tissues. ALKBH4 knockdown significantly induced the downregulation of NSCLC cell proliferation via cell cycle arrest at the G1 phase of in vivo tumour growth. ALKBH4 knockdown downregulated E2F transcription factor 1 (E2F1) and its target gene expression in NSCLC cells. ALKBH4 and E2F1 expression was significantly correlated in NSCLC clinical specimens. Moreover, patients with high ALKBH4 expression showed a poor prognosis, suggesting that ALKBH4 plays a pivotal tumour-promoting role in NSCLC.
format	article
author	Kentaro Jingushi Masaya Aoki Kazuhiro Ueda Takahiro Kogaki Masaya Tanimoto Yuya Monoe Masayuki Ando Takuya Matsumoto Kentaro Minami Yuko Ueda Kaori Kitae Hiroaki Hase Toshiyuki Nagata Aya Harada-Takeda Masatatsu Yamamoto Kohichi Kawahara Kazuhiro Tabata Tatsuhiko Furukawa Masami Sato Kazutake Tsujikawa
author_facet	Kentaro Jingushi Masaya Aoki Kazuhiro Ueda Takahiro Kogaki Masaya Tanimoto Yuya Monoe Masayuki Ando Takuya Matsumoto Kentaro Minami Yuko Ueda Kaori Kitae Hiroaki Hase Toshiyuki Nagata Aya Harada-Takeda Masatatsu Yamamoto Kohichi Kawahara Kazuhiro Tabata Tatsuhiko Furukawa Masami Sato Kazutake Tsujikawa
author_sort	Kentaro Jingushi
title	ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer
title_short	ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer
title_full	ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer
title_fullStr	ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer
title_full_unstemmed	ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer
title_sort	alkbh4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e39422a1faab4dfe81c736644fc55860
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ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer

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