Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery

Nur Akma Abdul Halim,1 Mohd Zobir Hussein,1 Mohd Khairuddin Kandar2 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, Seri Kembangan, Selangor Darul Ehsan, 43400, Malaysia; 2Department of Orthopedics, Faculty of Medicine and Health Sciences, Universiti Putra Mal...

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Autores principales:	Abdul Halim NA, Hussein MZ, Kandar MK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	hydroxyapatite nanocomposites physicochemical enhancement bone tissue engineering and drug carrier Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e397ac1dec1147f1888fbc1208f2528a
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spelling	oai:doaj.org-article:e397ac1dec1147f1888fbc1208f2528a2021-12-02T18:53:07ZNanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery1178-2013https://doaj.org/article/e397ac1dec1147f1888fbc1208f2528a2021-09-01T00:00:00Zhttps://www.dovepress.com/nanomaterials-upconverted-hydroxyapatite-for-bone-tissue-engineering-a-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Nur Akma Abdul Halim,1 Mohd Zobir Hussein,1 Mohd Khairuddin Kandar2 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, Seri Kembangan, Selangor Darul Ehsan, 43400, Malaysia; 2Department of Orthopedics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Selangor Darul Ehsan, 43400, MalaysiaCorrespondence: Mohd Zobir Hussein Email mzobir@upm.edu.myAbstract: Hydroxyapatite is a basic mineral that is very important to the human body framework. Recently, synthetic hydroxyapatite (SHA) and its nanocomposites (HANs) are the subject of intense research for bone tissue engineering and drug loading system applications, due to their unique, tailor-made characteristics, as well as their similarities with the bone mineral component in the human body. Although hydroxyapatite has good biocompatibility and osteoconductive characteristics, the poor mechanical strength restricts its use in non-load-bearing applications. Consequently, a rapid increase in reinforcing of other nanomaterials into hydroxyapatite for the formation of HANs could improve the mechanical properties. Most of the research reported on the success of other nanomaterials such as metals, ceramics and natural/synthetic polymers as additions into hydroxyapatite is reviewed. In addition, this review also focuses on the addition of various substances into hydroxyapatite for the formation of various HANs and at the same time to try to minimize the limitations so that various bone tissue engineering and drug loading system applications can be exploited.Keywords: hydroxyapatite, nanocomposites, physicochemical enhancement, bone tissue engineering and drug carrierAbdul Halim NAHussein MZKandar MKDove Medical Pressarticlehydroxyapatitenanocompositesphysicochemical enhancementbone tissue engineering and drug carrierMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 6477-6496 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hydroxyapatite nanocomposites physicochemical enhancement bone tissue engineering and drug carrier Medicine (General) R5-920
spellingShingle	hydroxyapatite nanocomposites physicochemical enhancement bone tissue engineering and drug carrier Medicine (General) R5-920 Abdul Halim NA Hussein MZ Kandar MK Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery
description	Nur Akma Abdul Halim,1 Mohd Zobir Hussein,1 Mohd Khairuddin Kandar2 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, Seri Kembangan, Selangor Darul Ehsan, 43400, Malaysia; 2Department of Orthopedics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Selangor Darul Ehsan, 43400, MalaysiaCorrespondence: Mohd Zobir Hussein Email mzobir@upm.edu.myAbstract: Hydroxyapatite is a basic mineral that is very important to the human body framework. Recently, synthetic hydroxyapatite (SHA) and its nanocomposites (HANs) are the subject of intense research for bone tissue engineering and drug loading system applications, due to their unique, tailor-made characteristics, as well as their similarities with the bone mineral component in the human body. Although hydroxyapatite has good biocompatibility and osteoconductive characteristics, the poor mechanical strength restricts its use in non-load-bearing applications. Consequently, a rapid increase in reinforcing of other nanomaterials into hydroxyapatite for the formation of HANs could improve the mechanical properties. Most of the research reported on the success of other nanomaterials such as metals, ceramics and natural/synthetic polymers as additions into hydroxyapatite is reviewed. In addition, this review also focuses on the addition of various substances into hydroxyapatite for the formation of various HANs and at the same time to try to minimize the limitations so that various bone tissue engineering and drug loading system applications can be exploited.Keywords: hydroxyapatite, nanocomposites, physicochemical enhancement, bone tissue engineering and drug carrier
format	article
author	Abdul Halim NA Hussein MZ Kandar MK
author_facet	Abdul Halim NA Hussein MZ Kandar MK
author_sort	Abdul Halim NA
title	Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery
title_short	Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery
title_full	Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery
title_fullStr	Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery
title_full_unstemmed	Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery
title_sort	nanomaterials-upconverted hydroxyapatite for bone tissue engineering and a platform for drug delivery
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e397ac1dec1147f1888fbc1208f2528a
work_keys_str_mv	AT abdulhalimna nanomaterialsupconvertedhydroxyapatiteforbonetissueengineeringandaplatformfordrugdelivery AT husseinmz nanomaterialsupconvertedhydroxyapatiteforbonetissueengineeringandaplatformfordrugdelivery AT kandarmk nanomaterialsupconvertedhydroxyapatiteforbonetissueengineeringandaplatformfordrugdelivery
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Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery

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