Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans
Human coronavirus-HKU1 contains two surface projections called spike and haemagglutinin-esterase (HE), with the latter acting as a receptor-destroying enzyme. Here, the authors use cryo-EM and mass spectrometry to characterise the small, heavily glycosylated HKU1 HE, revealing a vestigial lectin dom...
Guardado en:
Autores principales: | Daniel L. Hurdiss, Ieva Drulyte, Yifei Lang, Tatiana M. Shamorkina, Matti F. Pronker, Frank J. M. van Kuppeveld, Joost Snijder, Raoul J. de Groot |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/e39f8123487b43869c78601f60414a16 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution
por: Jinfang Yu, et al.
Publicado: (2020) -
Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1
por: Xiuyuan Ou, et al.
Publicado: (2017) -
Electrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses
por: Alireza Heidari, et al.
Publicado: (2018) -
Unique features of a recombinant haemagglutinin influenza vaccine that influence vaccine performance
por: Arun B. Arunachalam, et al.
Publicado: (2021) -
The impact of the butterfly effect on human parainfluenza virus haemagglutinin-neuraminidase inhibitor design
por: Larissa Dirr, et al.
Publicado: (2017)