7-Deazaguanine modifications protect phage DNA from host restriction systems

7-Deazaguanine modifications protect phage DNA from host restriction systems

Viral genomic DNA is often modified to evade the host bacterial restriction system. Here the authors identified 2′-deoxy-7-deazaguanine modifications on phage DNA by comparative genomics and experimental validation, showing their role in genome protection.

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Detalles Bibliográficos
Autores principales: Geoffrey Hutinet, Witold Kot, Liang Cui, Roman Hillebrand, Seetharamsingh Balamkundu, Shanmugavel Gnanakalai, Ramesh Neelakandan, Alexander B. Carstens, Chuan Fa Lui, Denise Tremblay, Deborah Jacobs-Sera, Mandana Sassanfar, Yan-Jiun Lee, Peter Weigele, Sylvain Moineau, Graham F. Hatfull, Peter C. Dedon, Lars H. Hansen, Valérie de Crécy-Lagard
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/e39fa27a9a6549e3ab545c4ecd3af0e2
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Sumario:Viral genomic DNA is often modified to evade the host bacterial restriction system. Here the authors identified 2′-deoxy-7-deazaguanine modifications on phage DNA by comparative genomics and experimental validation, showing their role in genome protection.

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