7-Deazaguanine modifications protect phage DNA from host restriction systems

Viral genomic DNA is often modified to evade the host bacterial restriction system. Here the authors identified 2′-deoxy-7-deazaguanine modifications on phage DNA by comparative genomics and experimental validation, showing their role in genome protection.

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Autores principales:	Geoffrey Hutinet, Witold Kot, Liang Cui, Roman Hillebrand, Seetharamsingh Balamkundu, Shanmugavel Gnanakalai, Ramesh Neelakandan, Alexander B. Carstens, Chuan Fa Lui, Denise Tremblay, Deborah Jacobs-Sera, Mandana Sassanfar, Yan-Jiun Lee, Peter Weigele, Sylvain Moineau, Graham F. Hatfull, Peter C. Dedon, Lars H. Hansen, Valérie de Crécy-Lagard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e39fa27a9a6549e3ab545c4ecd3af0e2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:e39fa27a9a6549e3ab545c4ecd3af0e22021-12-02T14:39:20Z7-Deazaguanine modifications protect phage DNA from host restriction systems10.1038/s41467-019-13384-y2041-1723https://doaj.org/article/e39fa27a9a6549e3ab545c4ecd3af0e22019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13384-yhttps://doaj.org/toc/2041-1723Viral genomic DNA is often modified to evade the host bacterial restriction system. Here the authors identified 2′-deoxy-7-deazaguanine modifications on phage DNA by comparative genomics and experimental validation, showing their role in genome protection.Geoffrey HutinetWitold KotLiang CuiRoman HillebrandSeetharamsingh BalamkunduShanmugavel GnanakalaiRamesh NeelakandanAlexander B. CarstensChuan Fa LuiDenise TremblayDeborah Jacobs-SeraMandana SassanfarYan-Jiun LeePeter WeigeleSylvain MoineauGraham F. HatfullPeter C. DedonLars H. HansenValérie de Crécy-LagardNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Geoffrey Hutinet Witold Kot Liang Cui Roman Hillebrand Seetharamsingh Balamkundu Shanmugavel Gnanakalai Ramesh Neelakandan Alexander B. Carstens Chuan Fa Lui Denise Tremblay Deborah Jacobs-Sera Mandana Sassanfar Yan-Jiun Lee Peter Weigele Sylvain Moineau Graham F. Hatfull Peter C. Dedon Lars H. Hansen Valérie de Crécy-Lagard 7-Deazaguanine modifications protect phage DNA from host restriction systems
description	Viral genomic DNA is often modified to evade the host bacterial restriction system. Here the authors identified 2′-deoxy-7-deazaguanine modifications on phage DNA by comparative genomics and experimental validation, showing their role in genome protection.
format	article
author	Geoffrey Hutinet Witold Kot Liang Cui Roman Hillebrand Seetharamsingh Balamkundu Shanmugavel Gnanakalai Ramesh Neelakandan Alexander B. Carstens Chuan Fa Lui Denise Tremblay Deborah Jacobs-Sera Mandana Sassanfar Yan-Jiun Lee Peter Weigele Sylvain Moineau Graham F. Hatfull Peter C. Dedon Lars H. Hansen Valérie de Crécy-Lagard
author_facet	Geoffrey Hutinet Witold Kot Liang Cui Roman Hillebrand Seetharamsingh Balamkundu Shanmugavel Gnanakalai Ramesh Neelakandan Alexander B. Carstens Chuan Fa Lui Denise Tremblay Deborah Jacobs-Sera Mandana Sassanfar Yan-Jiun Lee Peter Weigele Sylvain Moineau Graham F. Hatfull Peter C. Dedon Lars H. Hansen Valérie de Crécy-Lagard
author_sort	Geoffrey Hutinet
title	7-Deazaguanine modifications protect phage DNA from host restriction systems
title_short	7-Deazaguanine modifications protect phage DNA from host restriction systems
title_full	7-Deazaguanine modifications protect phage DNA from host restriction systems
title_fullStr	7-Deazaguanine modifications protect phage DNA from host restriction systems
title_full_unstemmed	7-Deazaguanine modifications protect phage DNA from host restriction systems
title_sort	7-deazaguanine modifications protect phage dna from host restriction systems
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e39fa27a9a6549e3ab545c4ecd3af0e2
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7-Deazaguanine modifications protect phage DNA from host restriction systems

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