7-Deazaguanine modifications protect phage DNA from host restriction systems

Viral genomic DNA is often modified to evade the host bacterial restriction system. Here the authors identified 2′-deoxy-7-deazaguanine modifications on phage DNA by comparative genomics and experimental validation, showing their role in genome protection.

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Geoffrey Hutinet, Witold Kot, Liang Cui, Roman Hillebrand, Seetharamsingh Balamkundu, Shanmugavel Gnanakalai, Ramesh Neelakandan, Alexander B. Carstens, Chuan Fa Lui, Denise Tremblay, Deborah Jacobs-Sera, Mandana Sassanfar, Yan-Jiun Lee, Peter Weigele, Sylvain Moineau, Graham F. Hatfull, Peter C. Dedon, Lars H. Hansen, Valérie de Crécy-Lagard
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e39fa27a9a6549e3ab545c4ecd3af0e2
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Soyez le premier à ajouter un commentaire!

7-Deazaguanine modifications protect phage DNA from host restriction systems

Documents similaires