Poly(2-(diethylamino)ethyl methacrylate)-based, pH-responsive, copolymeric mixed micelles for targeting anticancer drug control release

Quan Chen,1 Siheng Li,2 Zixiong Feng,1 Meng Wang,3 Chengzhi Cai,2 Jufang Wang,3 Lijuan Zhang1 1School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, People’s Republic of China; 2Department of Chemistry, University of Houston, Houston, TX, USA; 3Sch...

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Autores principales:	Chen Q, Li S, Feng Z, Wang M, Cai C, Wang J, Zhang L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	PDEAEMA pH-responsive mixed micelle control release Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e39fc42228744413b01caa0ad9f7e86d
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spelling	oai:doaj.org-article:e39fc42228744413b01caa0ad9f7e86d2021-12-02T01:04:56ZPoly(2-(diethylamino)ethyl methacrylate)-based, pH-responsive, copolymeric mixed micelles for targeting anticancer drug control release1178-2013https://doaj.org/article/e39fc42228744413b01caa0ad9f7e86d2017-09-01T00:00:00Zhttps://www.dovepress.com/poly2-diethylaminoethyl-methacrylate-based-ph-responsive-copolymeric-m-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Quan Chen,1 Siheng Li,2 Zixiong Feng,1 Meng Wang,3 Chengzhi Cai,2 Jufang Wang,3 Lijuan Zhang1 1School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, People’s Republic of China; 2Department of Chemistry, University of Houston, Houston, TX, USA; 3School of Bioscience & Bioengineering, South China University of Technology, Guangzhou, People’s Republic of China Abstract: We have demonstrated a novel drug delivery system to improve the selectivity of the current chemotherapy by pH-responsive, polymeric micelle carriers. The micelle carriers were prepared by the self-assembly of copolymers containing the polybasic poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA) block. The mixed copolymers exhibited a comparatively low critical micelle concentration (CMC; 1.95–5.25 mg/L). The resultant mixed micelles were found to be <100 nm and were used to encapsulate the anticancer drug doxorubicin (DOX) with pretty good drug-loading content (24%) and entrapment efficiency (55%). Most importantly, the micelle carrier exhibited a pH-dependent conformational conversion and promoted the DOX release at the tumorous pH. Our in vitro studies demonstrated the comparable level of DOX-loaded mixed micelle delivery into tumor cells with the free DOX (80% of the tumor cells were killed after 48 h incubation). The DOX-loaded mixed micelles were effective to inhibit the proliferation of tumor cells after prolonged incubation. Overall, the pH-responsive mixed micelle system provided desirable potential in the controlled release of anticancer therapeutics. Keywords: PDEAEMA, copolymers, pH-responsive, mixed micelle, DOX, targeting deliveryChen QLi SFeng ZWang MCai CWang JZhang LDove Medical PressarticlePDEAEMApH-responsivemixed micellecontrol releaseMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 6857-6870 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	PDEAEMA pH-responsive mixed micelle control release Medicine (General) R5-920
spellingShingle	PDEAEMA pH-responsive mixed micelle control release Medicine (General) R5-920 Chen Q Li S Feng Z Wang M Cai C Wang J Zhang L Poly(2-(diethylamino)ethyl methacrylate)-based, pH-responsive, copolymeric mixed micelles for targeting anticancer drug control release
description	Quan Chen,1 Siheng Li,2 Zixiong Feng,1 Meng Wang,3 Chengzhi Cai,2 Jufang Wang,3 Lijuan Zhang1 1School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, People’s Republic of China; 2Department of Chemistry, University of Houston, Houston, TX, USA; 3School of Bioscience & Bioengineering, South China University of Technology, Guangzhou, People’s Republic of China Abstract: We have demonstrated a novel drug delivery system to improve the selectivity of the current chemotherapy by pH-responsive, polymeric micelle carriers. The micelle carriers were prepared by the self-assembly of copolymers containing the polybasic poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA) block. The mixed copolymers exhibited a comparatively low critical micelle concentration (CMC; 1.95–5.25 mg/L). The resultant mixed micelles were found to be <100 nm and were used to encapsulate the anticancer drug doxorubicin (DOX) with pretty good drug-loading content (24%) and entrapment efficiency (55%). Most importantly, the micelle carrier exhibited a pH-dependent conformational conversion and promoted the DOX release at the tumorous pH. Our in vitro studies demonstrated the comparable level of DOX-loaded mixed micelle delivery into tumor cells with the free DOX (80% of the tumor cells were killed after 48 h incubation). The DOX-loaded mixed micelles were effective to inhibit the proliferation of tumor cells after prolonged incubation. Overall, the pH-responsive mixed micelle system provided desirable potential in the controlled release of anticancer therapeutics. Keywords: PDEAEMA, copolymers, pH-responsive, mixed micelle, DOX, targeting delivery
format	article
author	Chen Q Li S Feng Z Wang M Cai C Wang J Zhang L
author_facet	Chen Q Li S Feng Z Wang M Cai C Wang J Zhang L
author_sort	Chen Q
title	Poly(2-(diethylamino)ethyl methacrylate)-based, pH-responsive, copolymeric mixed micelles for targeting anticancer drug control release
title_short	Poly(2-(diethylamino)ethyl methacrylate)-based, pH-responsive, copolymeric mixed micelles for targeting anticancer drug control release
title_full	Poly(2-(diethylamino)ethyl methacrylate)-based, pH-responsive, copolymeric mixed micelles for targeting anticancer drug control release
title_fullStr	Poly(2-(diethylamino)ethyl methacrylate)-based, pH-responsive, copolymeric mixed micelles for targeting anticancer drug control release
title_full_unstemmed	Poly(2-(diethylamino)ethyl methacrylate)-based, pH-responsive, copolymeric mixed micelles for targeting anticancer drug control release
title_sort	poly(2-(diethylamino)ethyl methacrylate)-based, ph-responsive, copolymeric mixed micelles for targeting anticancer drug control release
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/e39fc42228744413b01caa0ad9f7e86d
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_version_	1718403350450405376

Poly(2-(diethylamino)ethyl methacrylate)-based, pH-responsive, copolymeric mixed micelles for targeting anticancer drug control release

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