Analysis of growth cone extension in standardized coordinates highlights self-organization rules during wiring of the Drosophila visual system.

A fascinating question in neuroscience is how ensembles of neurons, originating from different locations, extend to the proper place and by the right time to create precise circuits. Here, we investigate this question in the Drosophila visual system, where photoreceptors re-sort in the lamina to for...

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Autores principales:	Weiyue Ji, Lani F Wu, Steven J Altschuler
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/e39fcf2bdabe407e8813fd6771261b7b
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spelling	oai:doaj.org-article:e39fcf2bdabe407e8813fd6771261b7b2021-12-02T20:03:17ZAnalysis of growth cone extension in standardized coordinates highlights self-organization rules during wiring of the Drosophila visual system.1553-73901553-740410.1371/journal.pgen.1009857https://doaj.org/article/e39fcf2bdabe407e8813fd6771261b7b2021-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pgen.1009857https://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404A fascinating question in neuroscience is how ensembles of neurons, originating from different locations, extend to the proper place and by the right time to create precise circuits. Here, we investigate this question in the Drosophila visual system, where photoreceptors re-sort in the lamina to form the crystalline-like neural superposition circuit. The repeated nature of this circuit allowed us to establish a data-driven, standardized coordinate system for quantitative comparison of sparsely perturbed growth cones within and across specimens. Using this common frame of reference, we investigated the extension of the R3 and R4 photoreceptors, which is the only pair of symmetrically arranged photoreceptors with asymmetric target choices. Specifically, we found that extension speeds of the R3 and R4 growth cones are inherent to their cell identities. The ability to parameterize local regularity in tissue organization facilitated the characterization of ensemble cellular behaviors and dissection of mechanisms governing neural circuit formation.Weiyue JiLani F WuSteven J AltschulerPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 17, Iss 11, p e1009857 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Weiyue Ji Lani F Wu Steven J Altschuler Analysis of growth cone extension in standardized coordinates highlights self-organization rules during wiring of the Drosophila visual system.
description	A fascinating question in neuroscience is how ensembles of neurons, originating from different locations, extend to the proper place and by the right time to create precise circuits. Here, we investigate this question in the Drosophila visual system, where photoreceptors re-sort in the lamina to form the crystalline-like neural superposition circuit. The repeated nature of this circuit allowed us to establish a data-driven, standardized coordinate system for quantitative comparison of sparsely perturbed growth cones within and across specimens. Using this common frame of reference, we investigated the extension of the R3 and R4 photoreceptors, which is the only pair of symmetrically arranged photoreceptors with asymmetric target choices. Specifically, we found that extension speeds of the R3 and R4 growth cones are inherent to their cell identities. The ability to parameterize local regularity in tissue organization facilitated the characterization of ensemble cellular behaviors and dissection of mechanisms governing neural circuit formation.
format	article
author	Weiyue Ji Lani F Wu Steven J Altschuler
author_facet	Weiyue Ji Lani F Wu Steven J Altschuler
author_sort	Weiyue Ji
title	Analysis of growth cone extension in standardized coordinates highlights self-organization rules during wiring of the Drosophila visual system.
title_short	Analysis of growth cone extension in standardized coordinates highlights self-organization rules during wiring of the Drosophila visual system.
title_full	Analysis of growth cone extension in standardized coordinates highlights self-organization rules during wiring of the Drosophila visual system.
title_fullStr	Analysis of growth cone extension in standardized coordinates highlights self-organization rules during wiring of the Drosophila visual system.
title_full_unstemmed	Analysis of growth cone extension in standardized coordinates highlights self-organization rules during wiring of the Drosophila visual system.
title_sort	analysis of growth cone extension in standardized coordinates highlights self-organization rules during wiring of the drosophila visual system.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e39fcf2bdabe407e8813fd6771261b7b
work_keys_str_mv	AT weiyueji analysisofgrowthconeextensioninstandardizedcoordinateshighlightsselforganizationrulesduringwiringofthedrosophilavisualsystem AT lanifwu analysisofgrowthconeextensioninstandardizedcoordinateshighlightsselforganizationrulesduringwiringofthedrosophilavisualsystem AT stevenjaltschuler analysisofgrowthconeextensioninstandardizedcoordinateshighlightsselforganizationrulesduringwiringofthedrosophilavisualsystem
_version_	1718375693460439040

Analysis of growth cone extension in standardized coordinates highlights self-organization rules during wiring of the Drosophila visual system.

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