Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population

Abstract Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 g...

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Autores principales:	Sandra Romero-Hidalgo, José Flores-Rivera, Verónica Rivas-Alonso, Rodrigo Barquera, María Teresa Villarreal-Molina, Bárbara Antuna-Puente, Luis Rodrigo Macias-Kauffer, Marisela Villalobos-Comparán, Jair Ortiz-Maldonado, Neng Yu, Tatiana V. Lebedeva, Sharon M. Alosco, Juan Daniel García-Rodríguez, Carolina González-Torres, Sandra Rosas-Madrigal, Graciela Ordoñez, Jorge Luis Guerrero-Camacho, Irene Treviño-Frenk, Monica Escamilla-Tilch, Maricela García-Lechuga, Víctor Hugo Tovar-Méndez, Hanna Pacheco-Ubaldo, Victor Acuña-Alonzo, Maria-Cátira Bortolini, Carla Gallo, Gabriel Bedoya, Francisco Rothhammer, Rolando González-Jose, Andrés Ruiz-Linares, Samuel Canizales-Quinteros, Edmond Yunis, Julio Granados, Teresa Corona
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e39fd4e23a1a453796fed8b8df762e41
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spelling	oai:doaj.org-article:e39fd4e23a1a453796fed8b8df762e412021-12-02T18:50:53ZNative American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population10.1038/s41598-020-69224-32045-2322https://doaj.org/article/e39fd4e23a1a453796fed8b8df762e412020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-69224-3https://doaj.org/toc/2045-2322Abstract Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10–6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10–10). Class II HLA alleles HLA-DQB103:01, -DRB108:02, -DRB116:02, -DRB114:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.Sandra Romero-HidalgoJosé Flores-RiveraVerónica Rivas-AlonsoRodrigo BarqueraMaría Teresa Villarreal-MolinaBárbara Antuna-PuenteLuis Rodrigo Macias-KaufferMarisela Villalobos-ComparánJair Ortiz-MaldonadoNeng YuTatiana V. LebedevaSharon M. AloscoJuan Daniel García-RodríguezCarolina González-TorresSandra Rosas-MadrigalGraciela OrdoñezJorge Luis Guerrero-CamachoIrene Treviño-FrenkMonica Escamilla-TilchMaricela García-LechugaVíctor Hugo Tovar-MéndezHanna Pacheco-UbaldoVictor Acuña-AlonzoMaria-Cátira BortoliniCarla GalloGabriel BedoyaFrancisco RothhammerRolando González-JoseAndrés Ruiz-LinaresSamuel Canizales-QuinterosEdmond YunisJulio GranadosTeresa CoronaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sandra Romero-Hidalgo José Flores-Rivera Verónica Rivas-Alonso Rodrigo Barquera María Teresa Villarreal-Molina Bárbara Antuna-Puente Luis Rodrigo Macias-Kauffer Marisela Villalobos-Comparán Jair Ortiz-Maldonado Neng Yu Tatiana V. Lebedeva Sharon M. Alosco Juan Daniel García-Rodríguez Carolina González-Torres Sandra Rosas-Madrigal Graciela Ordoñez Jorge Luis Guerrero-Camacho Irene Treviño-Frenk Monica Escamilla-Tilch Maricela García-Lechuga Víctor Hugo Tovar-Méndez Hanna Pacheco-Ubaldo Victor Acuña-Alonzo Maria-Cátira Bortolini Carla Gallo Gabriel Bedoya Francisco Rothhammer Rolando González-Jose Andrés Ruiz-Linares Samuel Canizales-Quinteros Edmond Yunis Julio Granados Teresa Corona Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
description	Abstract Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10–6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10–10). Class II HLA alleles HLA-DQB103:01, -DRB108:02, -DRB116:02, -DRB114:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America.
format	article
author	Sandra Romero-Hidalgo José Flores-Rivera Verónica Rivas-Alonso Rodrigo Barquera María Teresa Villarreal-Molina Bárbara Antuna-Puente Luis Rodrigo Macias-Kauffer Marisela Villalobos-Comparán Jair Ortiz-Maldonado Neng Yu Tatiana V. Lebedeva Sharon M. Alosco Juan Daniel García-Rodríguez Carolina González-Torres Sandra Rosas-Madrigal Graciela Ordoñez Jorge Luis Guerrero-Camacho Irene Treviño-Frenk Monica Escamilla-Tilch Maricela García-Lechuga Víctor Hugo Tovar-Méndez Hanna Pacheco-Ubaldo Victor Acuña-Alonzo Maria-Cátira Bortolini Carla Gallo Gabriel Bedoya Francisco Rothhammer Rolando González-Jose Andrés Ruiz-Linares Samuel Canizales-Quinteros Edmond Yunis Julio Granados Teresa Corona
author_facet	Sandra Romero-Hidalgo José Flores-Rivera Verónica Rivas-Alonso Rodrigo Barquera María Teresa Villarreal-Molina Bárbara Antuna-Puente Luis Rodrigo Macias-Kauffer Marisela Villalobos-Comparán Jair Ortiz-Maldonado Neng Yu Tatiana V. Lebedeva Sharon M. Alosco Juan Daniel García-Rodríguez Carolina González-Torres Sandra Rosas-Madrigal Graciela Ordoñez Jorge Luis Guerrero-Camacho Irene Treviño-Frenk Monica Escamilla-Tilch Maricela García-Lechuga Víctor Hugo Tovar-Méndez Hanna Pacheco-Ubaldo Victor Acuña-Alonzo Maria-Cátira Bortolini Carla Gallo Gabriel Bedoya Francisco Rothhammer Rolando González-Jose Andrés Ruiz-Linares Samuel Canizales-Quinteros Edmond Yunis Julio Granados Teresa Corona
author_sort	Sandra Romero-Hidalgo
title	Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
title_short	Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
title_full	Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
title_fullStr	Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
title_full_unstemmed	Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population
title_sort	native american ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed mexican population
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e39fd4e23a1a453796fed8b8df762e41
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Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population

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