Loss of Upc2p-Inducible <italic toggle="yes">ERG3</italic> Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising <named-content content-type="genus-species">Candida albicans</named-content> Pathogenicity

Loss of Upc2p-Inducible <italic toggle="yes">ERG3</italic> Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising <named-content content-type="genus-species">Candida albicans</named-content> Pathogenicity

ABSTRACT Inactivation of sterol Δ5,6-desaturase (Erg3p) in the prevalent fungal pathogen Candida albicans is one of several mechanisms that can confer resistance to the azole antifungal drugs. However, loss of Erg3p activity is also associated with deficiencies in stress tolerance, invasive hyphal g...

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Autores principales: Arturo Luna-Tapia, Hubertine M. E. Willems, Josie E. Parker, Hélène Tournu, Katherine S. Barker, Andrew T. Nishimoto, P. David Rogers, Steven L. Kelly, Brian M. Peters, Glen E. Palmer
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
azole resistance
Candida albicans
disseminated candidiasis
ERG3
mouse models
pathogenesis
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/e3a04b7a36c249fbbe3ef214803936ec
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