p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1
Emerging studies suggest that p53 is an important regulator of energy metabolism, yet there is little known about the metabolic function of this tumor suppressor in the hypothalamus. Here, authors illustrate that p53, specifically in AgRP neurons, is required for adaptation to diet-induced obesity.
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2018
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oai:doaj.org-article:e3abcb467c8540338b4c0581b476791c2021-12-02T14:39:44Zp53 in AgRP neurons is required for protection against diet-induced obesity via JNK110.1038/s41467-018-05711-62041-1723https://doaj.org/article/e3abcb467c8540338b4c0581b476791c2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05711-6https://doaj.org/toc/2041-1723Emerging studies suggest that p53 is an important regulator of energy metabolism, yet there is little known about the metabolic function of this tumor suppressor in the hypothalamus. Here, authors illustrate that p53, specifically in AgRP neurons, is required for adaptation to diet-induced obesity.Mar QuiñonesOmar Al-MassadiCintia FolgueiraStephan BremserRosalía GallegoLeonardo Torres-LealRoberta Haddad-TóvolliCristina García-CaceresRene Hernandez-BautistaBrian Y. H. LamDaniel BeiroaEstrella Sanchez-RebordeloAna SenraJose A. MalagonPatricia ValerioMarcos F. FondevilaJohan FernøMaria M. MalagonRaian ContrerasPaul PflugerJens C. BrüningGiles YeoMatthias TschöpCarlos DiéguezMiguel LópezMarc ClaretPeter KloppenburgGuadalupe SabioRuben NogueirasNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Mar Quiñones Omar Al-Massadi Cintia Folgueira Stephan Bremser Rosalía Gallego Leonardo Torres-Leal Roberta Haddad-Tóvolli Cristina García-Caceres Rene Hernandez-Bautista Brian Y. H. Lam Daniel Beiroa Estrella Sanchez-Rebordelo Ana Senra Jose A. Malagon Patricia Valerio Marcos F. Fondevila Johan Fernø Maria M. Malagon Raian Contreras Paul Pfluger Jens C. Brüning Giles Yeo Matthias Tschöp Carlos Diéguez Miguel López Marc Claret Peter Kloppenburg Guadalupe Sabio Ruben Nogueiras p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 |
| description |
Emerging studies suggest that p53 is an important regulator of energy metabolism, yet there is little known about the metabolic function of this tumor suppressor in the hypothalamus. Here, authors illustrate that p53, specifically in AgRP neurons, is required for adaptation to diet-induced obesity. |
| format |
article |
| author |
Mar Quiñones Omar Al-Massadi Cintia Folgueira Stephan Bremser Rosalía Gallego Leonardo Torres-Leal Roberta Haddad-Tóvolli Cristina García-Caceres Rene Hernandez-Bautista Brian Y. H. Lam Daniel Beiroa Estrella Sanchez-Rebordelo Ana Senra Jose A. Malagon Patricia Valerio Marcos F. Fondevila Johan Fernø Maria M. Malagon Raian Contreras Paul Pfluger Jens C. Brüning Giles Yeo Matthias Tschöp Carlos Diéguez Miguel López Marc Claret Peter Kloppenburg Guadalupe Sabio Ruben Nogueiras |
| author_facet |
Mar Quiñones Omar Al-Massadi Cintia Folgueira Stephan Bremser Rosalía Gallego Leonardo Torres-Leal Roberta Haddad-Tóvolli Cristina García-Caceres Rene Hernandez-Bautista Brian Y. H. Lam Daniel Beiroa Estrella Sanchez-Rebordelo Ana Senra Jose A. Malagon Patricia Valerio Marcos F. Fondevila Johan Fernø Maria M. Malagon Raian Contreras Paul Pfluger Jens C. Brüning Giles Yeo Matthias Tschöp Carlos Diéguez Miguel López Marc Claret Peter Kloppenburg Guadalupe Sabio Ruben Nogueiras |
| author_sort |
Mar Quiñones |
| title |
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 |
| title_short |
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 |
| title_full |
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 |
| title_fullStr |
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 |
| title_full_unstemmed |
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 |
| title_sort |
p53 in agrp neurons is required for protection against diet-induced obesity via jnk1 |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/e3abcb467c8540338b4c0581b476791c |
| work_keys_str_mv |
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