DCAF1 controls T-cell function via p53-dependent and -independent mechanisms

DCAF1 (VprBP), an HIV target protein, is a component of an ubiquitin ligase complex involved in developmental processes in plants and animals. Here, DCAF1 is shown to be vital for activation-induced T cell growth and proliferation, partly by being required for p53’s ubiquitination and degradation.

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Autores principales:	Zengli Guo, Qing Kong, Cui Liu, Song Zhang, Liyun Zou, Feng Yan, Jason K. Whitmire, Yue Xiong, Xian Chen, Yisong Y. Wan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e3ad2463a41e46ce80707481ab85705f
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spelling	oai:doaj.org-article:e3ad2463a41e46ce80707481ab85705f2021-12-02T17:32:06ZDCAF1 controls T-cell function via p53-dependent and -independent mechanisms10.1038/ncomms103072041-1723https://doaj.org/article/e3ad2463a41e46ce80707481ab85705f2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10307https://doaj.org/toc/2041-1723DCAF1 (VprBP), an HIV target protein, is a component of an ubiquitin ligase complex involved in developmental processes in plants and animals. Here, DCAF1 is shown to be vital for activation-induced T cell growth and proliferation, partly by being required for p53’s ubiquitination and degradation.Zengli GuoQing KongCui LiuSong ZhangLiyun ZouFeng YanJason K. WhitmireYue XiongXian ChenYisong Y. WanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zengli Guo Qing Kong Cui Liu Song Zhang Liyun Zou Feng Yan Jason K. Whitmire Yue Xiong Xian Chen Yisong Y. Wan DCAF1 controls T-cell function via p53-dependent and -independent mechanisms
description	DCAF1 (VprBP), an HIV target protein, is a component of an ubiquitin ligase complex involved in developmental processes in plants and animals. Here, DCAF1 is shown to be vital for activation-induced T cell growth and proliferation, partly by being required for p53’s ubiquitination and degradation.
format	article
author	Zengli Guo Qing Kong Cui Liu Song Zhang Liyun Zou Feng Yan Jason K. Whitmire Yue Xiong Xian Chen Yisong Y. Wan
author_facet	Zengli Guo Qing Kong Cui Liu Song Zhang Liyun Zou Feng Yan Jason K. Whitmire Yue Xiong Xian Chen Yisong Y. Wan
author_sort	Zengli Guo
title	DCAF1 controls T-cell function via p53-dependent and -independent mechanisms
title_short	DCAF1 controls T-cell function via p53-dependent and -independent mechanisms
title_full	DCAF1 controls T-cell function via p53-dependent and -independent mechanisms
title_fullStr	DCAF1 controls T-cell function via p53-dependent and -independent mechanisms
title_full_unstemmed	DCAF1 controls T-cell function via p53-dependent and -independent mechanisms
title_sort	dcaf1 controls t-cell function via p53-dependent and -independent mechanisms
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e3ad2463a41e46ce80707481ab85705f
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DCAF1 controls T-cell function via p53-dependent and -independent mechanisms

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