DCAF1 controls T-cell function via p53-dependent and -independent mechanisms

DCAF1 controls T-cell function via p53-dependent and -independent mechanisms

DCAF1 (VprBP), an HIV target protein, is a component of an ubiquitin ligase complex involved in developmental processes in plants and animals. Here, DCAF1 is shown to be vital for activation-induced T cell growth and proliferation, partly by being required for p53’s ubiquitination and degradation.

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Autores principales: Zengli Guo, Qing Kong, Cui Liu, Song Zhang, Liyun Zou, Feng Yan, Jason K. Whitmire, Yue Xiong, Xian Chen, Yisong Y. Wan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/e3ad2463a41e46ce80707481ab85705f
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